The influence of the dietary exposome on oxidative stress in pregnancy complications

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dc.contributor.authorPrins, Jelmer R.
dc.contributor.authorSchoots, Mirthe H.
dc.contributor.authorWessels, Jule I.
dc.contributor.authorCampmans-Kuijpers, Marjo J.E.
dc.contributor.authorNavis, Gerjan J.
dc.contributor.authorvan Goor, Harry
dc.contributor.authorRobertson, Sarah A.
dc.contributor.authorvan der Beek, Eline M.
dc.contributor.authorSobrevia, Luis [UNESP]
dc.contributor.authorGordijn, Sanne J.
dc.contributor.institutionUniversity of Groningen
dc.contributor.institutionUniversity of Adelaide
dc.contributor.institutionNestlé Research
dc.contributor.institutionPontificia Universidad Católica de Chile
dc.contributor.institutionUniversidad de Sevilla
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Queensland
dc.contributor.institutionSchool of Medicine and Health Sciences
dc.date.accessioned2022-04-28T19:52:53Z
dc.date.available2022-04-28T19:52:53Z
dc.date.issued2022-01-01
dc.description.abstractPregnancy complications including fetal growth restriction, preeclampsia, and preterm birth, as well as gestational diabetes, affect one in every four to five pregnancies. Accumulating evidence indicates that increased production of reactive oxygen species accompanies these complications. Given that reactive oxygen species are cell stress-inducing agents, they may have a causal role in disease pathophysiology, although the exact mechanisms by which they contribute to pregnancy complications are not completely understood. Since many environmental and lifestyle factors and exposures are known to modulate reactive oxygen species production, the exposome of pregnant women could contribute to increased generation of reactive oxygen species. The objective of this review is to provide a comprehensive overview of the endogenous and exogenous exposome factors that regulate reactive species in healthy and complicated pregnancies. We also provide a description of dietary interventions aimed at the reduction of reactive species in order to attenuate adverse pregnancy outcome. Dietary interventions in general hold minimal risk in pregnancy and could therefore be considered a promising therapeutic approach.en
dc.description.affiliationDepartment of Obstetrics and Gynaecology University Medical Center Groningen (UMCG) University of Groningen
dc.description.affiliationDepartment of Pathology and Medical Biology Division of Pathology UMCG University of Groningen
dc.description.affiliationDepartment of Gastroenterology and Hepatology UMCG University of Groningen
dc.description.affiliationDepartment of Medicine Division of Nephrology UMCG University of Groningen
dc.description.affiliationRobinson Research Institute and Adelaide Medical School University of Adelaide
dc.description.affiliationDepartment of Pediatrics UMCG University of Groningen
dc.description.affiliationNestlé Institute of Health Sciences Nestlé Research
dc.description.affiliationCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile
dc.description.affiliationDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla
dc.description.affiliationMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)
dc.description.affiliationUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland
dc.description.affiliationTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences, Nuevo León
dc.description.affiliationUnespMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)
dc.description.sponsorshipRijksuniversiteit Groningen
dc.description.sponsorshipFondo Nacional de Desarrollo Científico y Tecnológico
dc.description.sponsorshipIdFondo Nacional de Desarrollo Científico y Tecnológico: 1190316
dc.identifierhttp://dx.doi.org/10.1016/j.mam.2022.101098
dc.identifier.citationMolecular Aspects of Medicine.
dc.identifier.doi10.1016/j.mam.2022.101098
dc.identifier.issn1872-9452
dc.identifier.issn0098-2997
dc.identifier.scopus2-s2.0-85127487731
dc.identifier.urihttp://hdl.handle.net/11449/223755
dc.language.isoeng
dc.relation.ispartofMolecular Aspects of Medicine
dc.sourceScopus
dc.subjectDiet
dc.subjectExposome
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectPlacenta
dc.subjectPregnancy
dc.titleThe influence of the dietary exposome on oxidative stress in pregnancy complicationsen
dc.typeResenha
unesp.author.orcid0000-0002-3984-2163[1]

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