The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin

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dc.contributor.authorde Farias, Aline Leite [UNESP]
dc.contributor.authorMeneguin, Andréia Bagliotti [UNESP]
dc.contributor.authorda Silva Barud, Hernane
dc.contributor.authorBrighenti, Fernanda Lourenção [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Araraquara - UNIARA
dc.date.accessioned2020-12-12T02:20:21Z
dc.date.available2020-12-12T02:20:21Z
dc.date.issued2020-11-01
dc.description.abstractThe use of controlled drug delivery systems represents an alternative and promising strategy for the use of antimicrobials in the oral cavity. Microparticles, films and oral tablets based on alginate and gellan gum were developed also as a strategy to overcome the low aqueous solubility of morin. The systems were characterized in terms of morphological characteristics, mucoadhesion and in vitro drug release. Antibiofilm activity was analyzed for acidogenicity, microbial viability and the composition of the extracellular matrix of single-species biofilms. Scanning Electron Microscopy demonstrated that the microparticles were spherical, rough and compact. The film and the tablet presented smooth and continuous surface and in the inner of the tablet was porous. These systems were more mucoadhesive compared to the microparticles. The in vitro morin release profiles in artificial saliva demonstrated that the microparticles controlled the release better (39.6%), followed by the film (41.1%) and the tablet (91.4%) after 20 h of testing. The morin released from the systems reduced the acidogenicity, microbial viability, concentration of insoluble extracellular polysaccharides and dry weight of biofilms, when compared to the control group. The findings of this study showed that the morin has antibiofilm activity against cariogenic microorganisms.en
dc.description.affiliationDepartment of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University - UNESP
dc.description.affiliationDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University-UNESP
dc.description.affiliationBiopolymers and Biomaterials Laboratory (BioPolMat) University of Araraquara - UNIARA
dc.description.affiliationUnespDepartment of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University - UNESP
dc.description.affiliationUnespDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University-UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2013/07276-1
dc.description.sponsorshipIdFAPESP: 2013/12326-8
dc.description.sponsorshipIdFAPESP: 2018/25512-8
dc.description.sponsorshipIdCNPq: 304383/2016­3
dc.description.sponsorshipIdCNPq: 407822/2018-6
dc.description.sponsorshipIdFAPESP: CEPID - 13/07276-1
dc.format.extent1944-1958
dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2020.08.078
dc.identifier.citationInternational Journal of Biological Macromolecules, v. 162, p. 1944-1958.
dc.identifier.doi10.1016/j.ijbiomac.2020.08.078
dc.identifier.issn1879-0003
dc.identifier.issn0141-8130
dc.identifier.lattes6065636367717382
dc.identifier.orcid0000-0002-4470-5171
dc.identifier.scopus2-s2.0-85089839395
dc.identifier.urihttp://hdl.handle.net/11449/200950
dc.language.isoeng
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.sourceScopus
dc.subjectAlginate
dc.subjectControlled drug delivery
dc.subjectDental plaque
dc.subjectGellan gum
dc.subjectMorin hydrate
dc.subjectPolysaccharides
dc.titleThe role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morinen
dc.typeArtigo
unesp.author.lattes6065636367717382[4]
unesp.author.orcid0000-0002-4470-5171[4]

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