Sensor array made with nanostructured films to detect a phenothiazine compound

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dc.contributor.authorAoki, P. H. B. [UNESP]
dc.contributor.authorCaetano, Wilker [UNESP]
dc.contributor.authorVolpati, D. [UNESP]
dc.contributor.authorRiul, A.
dc.contributor.authorConstantino, C. J. L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T13:23:13Z
dc.date.available2014-05-20T13:23:13Z
dc.date.issued2008-09-01
dc.description.abstractThe detection of trace amounts of phenothiazines with fast, direct methods is important for medical applications and the pharmaceutical industry. In this paper we explore the concept of an electronic tongue to detect methylene blue (MB), with a sensor array comprising 6 units. These units were a bare Pt electrode, and Pt electrodes coated with 1-layer LB films of dipalmitoyl phosphatidylcholine (DPPC) and dipalmitoyl phosphatidylglycerol (DPPG), a 5-layer LB film of stearic acid, and 10 nm PVD films of bis benzimidazo perylene (AzoPTCD) and iron phthalocyanine (FePc). The electrical response obtained with impedance spectroscopy varied with the sensing unit, in spite of the small film thickness, thus indicating good cross-sensitivity. Upon treating the capacitance data at 1 kHz with Principal Component Analysis (PCA), the sensor array was capable of distinguishing MB solutions from ultrapure water down to 1 nM. This unprecedented high sensitivity was probably due to strong interactions between MB and DPPC and DPPG, as the sensing units of these phospholipids gave the most important contributions to the PCA plots. Such strong interaction was not manifested in the surface pressure-area isotherms of co-spread monolayers of MB and DPPC or DPPG, which emphasizes the high sensitivity of the electrical measurements in ultrathin films in contact with liquids, now widely exploited in electronic tongues.en
dc.description.affiliationUNESP, Fac Ciencias & Tecnol, DFQB, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), BR-18043970 São Carlos, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias & Tecnol, DFQB, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 06/57132-2
dc.format.extent4341-4348
dc.identifierhttp://dx.doi.org/10.1166/jnn.2008.297
dc.identifier.citationJournal of Nanoscience and Nanotechnology. Stevenson Ranch: Amer Scientific Publishers, v. 8, n. 9, p. 4341-4348, 2008.
dc.identifier.doi10.1166/jnn.2008.297
dc.identifier.issn1533-4880
dc.identifier.lattes7384168674539702
dc.identifier.orcid0000-0003-4701-6408
dc.identifier.urihttp://hdl.handle.net/11449/6970
dc.identifier.wosWOS:000260776900004
dc.language.isoeng
dc.publisherAmer Scientific Publishers
dc.relation.ispartofJournal of Nanoscience and Nanotechnology
dc.relation.ispartofjcr1.354
dc.relation.ispartofsjr0,326
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPhospholipidsen
dc.subjectPhenothiazineen
dc.subjectSensorsen
dc.titleSensor array made with nanostructured films to detect a phenothiazine compounden
dc.typeArtigo
dcterms.licensehttp://www.aspbs.com/jnn/JNN%20Copyright%20Transfer%20Form.pdf
dcterms.rightsHolderAmer Scientific Publishers
unesp.author.lattes7384168674539702[1]
unesp.author.lattes6118325967319836[5]
unesp.author.orcid0000-0003-4370-5492[3]
unesp.author.orcid0000-0002-9760-1851[4]
unesp.author.orcid0000-0003-4701-6408[1]
unesp.author.orcid0000-0002-5921-3161[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Tecnologia, Presidente Prudentept

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