SFlt-1/PlGF ratio as a prognostic marker of adverse outcomes in women with early-onset preeclampsia

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dc.contributor.authorOliveira, Leandro Gustavo de [UNESP]
dc.contributor.authorPeraçoli, José Carlos [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.authorKorkes, Henri
dc.contributor.authorZampieri, Giafranco
dc.contributor.authorMoron, Antonio F.
dc.contributor.authorSass, Nelson
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHospital e Maternidade Vila Nova Cachoeirinha
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLaboratory of Clinical Pathology Salomão and Zoppi
dc.date.accessioned2014-05-27T11:29:49Z
dc.date.available2014-05-27T11:29:49Z
dc.date.issued2013-07-01
dc.description.abstractSoluble fms-like tyrosine kinase 1 (sFlt-1) is an anti-angiogenic factor released in higher amounts by preeclamptic placentas and it has been implicated in the endothelial dysfunction observed in the disease. In this study we evaluated if circulating sFlt-1/PlGF ratio is useful to predict adverse outcomes in women with early-onset preeclampsia. This is a cohort study of 88 preeclamptic women with singleton pregnancies at ≤35 weeks of gestation. According to definitions used, adverse outcomes occurred in 46.5% (N = 43) of the patients. The median sFlt1/PlGF ratio (25th-75th centile) for all patients evaluated was of 42.26 (13.1-226.1). The median sFlt-1/PlGF ratio among women who had any adverse outcome (N = 43) versus no adverse outcomes (N = 45) was of 227.6 (80.3-346.1) versus 14.4 (3.35-30.0), (P < 0.0001). According to our analyses a sFlt-1/PlGF ratio cut-point of ≥85 gave a sensitivity of 74.0% and specificity of 97.0%. The positive predictive value and the negative predictive value were 96.0% and 80.0%, respectively. The median sFlt-1/PlGF ratio (25th-75th centile) for patients who delivered within <7 days was 260.0 (127.7-404.7) as compared to 14.4 (3.35-34.97) for those patients who delivered within two weeks or more (P < 0.0001). Our results suggest that sFlt-1/PlGF ratio is a promising marker for adverse outcomes in women with early-onset preeclampsia. © 2013 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationObstetrics Department Universidade Federal de São Paulo, 875 Vila Clementino, São Paulo 04024
dc.description.affiliationLaboratory of Clinical and Experimental Investigation Hospital e Maternidade Vila Nova Cachoeirinha, São Paulo
dc.description.affiliationObstetrics Department Universidade Estadual Paulista, Botucatu
dc.description.affiliationLaboratory of Clinical Pathology Salomão and Zoppi, São Paulo
dc.description.affiliationUnespObstetrics Department Universidade Estadual Paulista, Botucatu
dc.format.extent191-195
dc.identifierhttp://dx.doi.org/10.1016/j.preghy.2013.02.003
dc.identifier.citationPregnancy Hypertension, v. 3, n. 3, p. 191-195, 2013.
dc.identifier.doi10.1016/j.preghy.2013.02.003
dc.identifier.issn2210-7789
dc.identifier.lattes8499437381595614
dc.identifier.lattes0720794820325913
dc.identifier.lattes6486557387397806
dc.identifier.scopus2-s2.0-84878870151
dc.identifier.urihttp://hdl.handle.net/11449/75775
dc.language.isoeng
dc.relation.ispartofPregnancy Hypertension
dc.relation.ispartofjcr2.011
dc.relation.ispartofsjr1,205
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectInflammation
dc.subjectPlGF
dc.subjectPreeclampsia
dc.subjectsFlt-1
dc.subjectplacental growth factor
dc.subjectvasculotropin receptor 1
dc.subjectadult
dc.subjectBrazil
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectdiagnostic test accuracy study
dc.subjectdisease marker
dc.subjectfemale
dc.subjectgestational age
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectpredictive value
dc.subjectpreeclampsia
dc.subjectpregnancy outcome
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectprotein blood level
dc.subjectreceiver operating characteristic
dc.subjectsensitivity and specificity
dc.titleSFlt-1/PlGF ratio as a prognostic marker of adverse outcomes in women with early-onset preeclampsiaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes0720794820325913
unesp.author.lattes8499437381595614
unesp.author.lattes6486557387397806
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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