Caracterização do microbioma intestinal de homens brasileiros com psoríase em comparação com controles onívoros e vegetarianos
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Data
2022-09-22
Autores
Polo, Tatiana Cristina Figueira
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Universidade Estadual Paulista (Unesp)
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FUNDAMENTOS: Psoríase é doença inflamatória crônica, associada a inflamação sistêmica e comorbidades. Alterações na composição do microbioma intestinal são envolvidas na patogênese de doenças inflamatórias e síndrome metabólica. Caracterizar o microbioma intestinal de pacientes com psoríase pode ser relevante no entendimento de seu curso clínico e na prevenção de comorbidades. OBJETIVO: Caracterização do microbioma intestinal de homens com psoríase em comparação com controles (sem psoríase) onívoros e vegetarianos. MÉTODO: Estudo transversal envolvendo 42 homens adultos: 21 onívoros com psoríase; e controles: 14 onívoros e 7 vegetarianos. A caracterização do microbioma intestinal foi realizada por análise metagenômica. Avaliaram-se os níveis séricos da proteína ligadora de lipopolissacarídeo (LPB) e proteína C reativa (PCR). RESULTADOS: Os grupos diferiram entre si quanto a aspectos nutricionais e do microbioma, indivíduos com psoríase apresentaram maior consumo de proteínas, e menor de fibras. Níveis de LPB, PCR e a relação Firmicutes/Bacteroidetes foi maior no grupo com psoríase que no grupo vegetariano (p<0,05). Os gêneros Prevotella, Mogibacterium, Dorea, Bifidobacterium e Coprococcus, diferiram no grupo com psoríase em comparação com vegetarianos; já os gêneros Mogibacterium, Collinsella e Desulfovibrio, diferiram dos onívoros. Identificou-se um padrão de microbioma ligado à psoríase (plsPSO) que se associou a maiores níveis de LPB (rho=0,39; p=0,02), e menor ingesta de fibras dietéticas (rho=-0,71; p<0,01). LIMITAÇÕES: Avaliaram-se apenas homens adultos. CONCLUSÃO: Houve diferença no microbioma intestinal de homens adultos com psoríase, em relação a onívoros e vegetarianos saudáveis. O padrão de microbioma encontrado correlacionou-se com a ingesta de fibras alimentares, e com os níveis séricos de LPB.
BACKGROUND: Psoriasis is a chronic inflammatory disease associated with systemic diseases and comorbidities. Changes in the composition of the gut microbiome are involved in the pathogenesis of inflammatory and metabolic diseases. Characterizing the gut microbiome in patients with psoriasis may be relevant to understanding clinical course and preventing comorbidities. OBJECTIVE: Characterization of the gut microbiome of men with psoriasis compared with omnivorous and vegetarian (non-psoriasis) controls. METHOD: Cross-sectional study involving 42 adult men: 21 omnivores with psoriasis; and controls: 14 omnivores and 7 vegetarians. The characterization of the gut microbiome was performed by metagenomic analysis. Serum levels of lipopolysaccharide binding protein (LPB) and C-reactive protein (CRP) were evaluated. RESULTS: The nutritional and microbiome groups differed from each other in terms of higher protein consumption with psoriasis, and lower fiber consumption. Levels of LPB, CRP and the Firmicutes/Bacteroidetes ratio were higher in the psoriasis group than in the vegetarian group (p<0.05). The genera Prevotella, Mogibacterium, Dorea, Bifidobacterium and Coprococcus differed in the psoriasis group compared to vegetarians; The genera Mogibacterium, Collinsella and Desulfovibrio, however, differed from the omnivores. A psoriasis-linked microbiome pattern (plsPSO) was identified that is associated with higher levels of LPB (rho=0.39; p=0.02), and lower dietary fiber intake (rho=-0.71; p <0.01). LIMITATIONS: Only adult males were evaluated. CONCLUSION: There was a difference in the gut microbiome of adult men with psoriasis, compared to omnivores and vegetarian men. The microbiome pattern found correlated with an intake of dietary fiber, and with serum levels of LPB.
BACKGROUND: Psoriasis is a chronic inflammatory disease associated with systemic diseases and comorbidities. Changes in the composition of the gut microbiome are involved in the pathogenesis of inflammatory and metabolic diseases. Characterizing the gut microbiome in patients with psoriasis may be relevant to understanding clinical course and preventing comorbidities. OBJECTIVE: Characterization of the gut microbiome of men with psoriasis compared with omnivorous and vegetarian (non-psoriasis) controls. METHOD: Cross-sectional study involving 42 adult men: 21 omnivores with psoriasis; and controls: 14 omnivores and 7 vegetarians. The characterization of the gut microbiome was performed by metagenomic analysis. Serum levels of lipopolysaccharide binding protein (LPB) and C-reactive protein (CRP) were evaluated. RESULTS: The nutritional and microbiome groups differed from each other in terms of higher protein consumption with psoriasis, and lower fiber consumption. Levels of LPB, CRP and the Firmicutes/Bacteroidetes ratio were higher in the psoriasis group than in the vegetarian group (p<0.05). The genera Prevotella, Mogibacterium, Dorea, Bifidobacterium and Coprococcus differed in the psoriasis group compared to vegetarians; The genera Mogibacterium, Collinsella and Desulfovibrio, however, differed from the omnivores. A psoriasis-linked microbiome pattern (plsPSO) was identified that is associated with higher levels of LPB (rho=0.39; p=0.02), and lower dietary fiber intake (rho=-0.71; p <0.01). LIMITATIONS: Only adult males were evaluated. CONCLUSION: There was a difference in the gut microbiome of adult men with psoriasis, compared to omnivores and vegetarian men. The microbiome pattern found correlated with an intake of dietary fiber, and with serum levels of LPB.
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Palavras-chave
Microbioma gastrointestinal, Dieta, Dieta vegetariana, Dieta ocidental, Obesidade, Microbiota, Psoríase, Gastrointestinal microbiome, Diet, Vegetarian diet, Western diet, Obesity, Microbiota, Psoriasis