Combining Landscape Genomics and Ecological Modelling to Investigate Local Adaptation of Indigenous Ugandan Cattle to East Coast Fever

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dc.contributor.authorVajana, Elia
dc.contributor.authorBarbato, Mario
dc.contributor.authorColli, Licia
dc.contributor.authorMilanesi, Marco [UNESP]
dc.contributor.authorRochat, Estelle
dc.contributor.authorFabrizi, Enrico
dc.contributor.authorMukasa, Christopher
dc.contributor.authorDel Corvo, Marcello
dc.contributor.authorMasembe, Charles
dc.contributor.authorMuwanika, Vincent B.
dc.contributor.authorKabi, Fredrick
dc.contributor.authorSonstegard, Tad Stewart
dc.contributor.authorHuson, Heather Jay
dc.contributor.authorNegrini, Riccardo
dc.contributor.authorJoost, Stephane
dc.contributor.authorAjmone-Marsan, Paolo
dc.contributor.authorNextGen Consortium
dc.contributor.institutionUniv Cattolica Sacro Cuore
dc.contributor.institutionEcole Polytech Fed Lausanne
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionIAEA
dc.contributor.institutionNatl Anim Genet Resource Ctr
dc.contributor.institutionData Bank
dc.contributor.institutionMakerere Univ
dc.contributor.institutionNatl Agr Res Org
dc.contributor.institutionRecombinetics Inc
dc.contributor.institutionCornell Univ
dc.contributor.institutionAIA
dc.date.accessioned2019-10-04T12:30:59Z
dc.date.available2019-10-04T12:30:59Z
dc.date.issued2018-10-03
dc.description.abstractEast Coast fever (ECF) is a fatal sickness affecting cattle populations of eastern, central, and southern Africa. The disease is transmitted by the tick Rhipicephalus appendiculatus, and caused by the protozoan Theileria parva parva, which invades host lymphocytes and promotes their clonal expansion. Importantly, indigenous cattle show tolerance to infection in ECF-endemically stable areas. Here, the putative genetic bases underlying ECF-tolerance were investigated using molecular data and epidemiological information from 823 indigenous cattle from Uganda. Vector distribution and host infection risk were estimated over the study area and subsequently tested as triggers of local adaptation by means of landscape genomics analysis. We identified 41 and seven candidate adaptive loci for tick resistance and infection tolerance, respectively. Among the genes associated with the candidate adaptive loci are PRKG1 and SLA2. PRKG1 was already described as associated with tick resistance in indigenous South African cattle, due to its role into inflammatory response. SLA2 is part of the regulatory pathways involved into lymphocytes' proliferation. Additionally, local ancestry analysis suggested the zebuine origin of the genomic region candidate for tick resistance.en
dc.description.affiliationUniv Cattolica Sacro Cuore, Biodivers & Ancient DNA Res Ctr BioDNA, Dept Anim Sci Food & Nutr DIANA, Piacenza, Italy
dc.description.affiliationUniv Cattolica Sacro Cuore, Prote & Nutrigen Res Ctr PRONUTRIGEN, Piacenza, Italy
dc.description.affiliationEcole Polytech Fed Lausanne, Sch Architecture Civil & Environm Engn ENAC, Lab Geog Informat Syst LASIG, Lausanne, Switzerland
dc.description.affiliationSao Paulo State Univ, Sch Vet Med, Dept Support Prod & Anim Hlth, Aracatuba, Brazil
dc.description.affiliationIAEA, Collaborating Ctr Anim Genom & Bioinformat, Aracatuba, Brazil
dc.description.affiliationUniv Cattolica Sacro Cuore, Dept Econ & Social Sci, Piacenza, Italy
dc.description.affiliationNatl Anim Genet Resource Ctr, Entebbe, Uganda
dc.description.affiliationData Bank, Entebbe, Uganda
dc.description.affiliationMakerere Univ, Dept Zool Entomol & Fisheries, Kampala, Uganda
dc.description.affiliationMakerere Univ, Dept Environm Management, Kampala, Uganda
dc.description.affiliationNatl Agr Res Org, Natl Livestock Resources Res Inst NaLIRRI, Tororo, Uganda
dc.description.affiliationRecombinetics Inc, St Paul, MN USA
dc.description.affiliationCornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA
dc.description.affiliationAIA, Rome, Italy
dc.description.affiliationUnespSao Paulo State Univ, Sch Vet Med, Dept Support Prod & Anim Hlth, Aracatuba, Brazil
dc.description.sponsorshipEuropean Union
dc.description.sponsorshipDoctoral School on the Agro-Food System (Agrisystem) of the Universita Cattolica del Sacro Cuore (Italy)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdEuropean Union: 244356-NextGen
dc.description.sponsorshipIdEuropean Union: KBBE-2009-1-1-03
dc.description.sponsorshipIdFAPESP: 2016/05787-7
dc.format.extent16
dc.identifierhttp://dx.doi.org/10.3389/fgene.2018.00385
dc.identifier.citationFrontiers In Genetics. Lausanne: Frontiers Media Sa, v. 9, 16 p., 2018.
dc.identifier.doi10.3389/fgene.2018.00385
dc.identifier.issn1664-8021
dc.identifier.urihttp://hdl.handle.net/11449/184898
dc.identifier.wosWOS:000446326000001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Genetics
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectlocal adaptation
dc.subjectlandscape genomics
dc.subjectspecies distribution modelling
dc.subjectindigenous cattle
dc.subjectEast Coast fever
dc.titleCombining Landscape Genomics and Ecological Modelling to Investigate Local Adaptation of Indigenous Ugandan Cattle to East Coast Feveren
dc.typeArtigo
dcterms.rightsHolderFrontiers Media Sa
unesp.author.orcid0000-0002-9581-0414[9]
unesp.author.orcid0000-0002-1184-7501[15]

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