Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: influence of sodium intake

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dc.contributor.authorDalmasso, Carolina
dc.contributor.authorAntunes-Rodrigues, José
dc.contributor.authorVivas, Laura
dc.contributor.authorDe Luca, Laurival A. [UNESP]
dc.contributor.institutionUniversidad Nacional de Córdoba
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:40:26Z
dc.date.available2015-12-07T15:40:26Z
dc.date.issued2015-11-01
dc.description.abstractWater deprivation (WD) followed by water intake to satiety, produces satiation of thirst and partial rehydration (PR). Thus, WD-PR is a natural method to differentiate thirst from sodium appetite. WD-PR also produces Fos immunoreactivity (Fos-ir) in interconnected areas of a brain circuit postulated to subserve sodium appetite. In the present work, we evaluated the effect of sodium intake on Fos-ir produced by WD-PR in brain areas operationally defined according to the literature as either facilitatory or inhibitory to sodium intake. Isotonic NaCl was available for ingestion in a sodium appetite test performed immediately after a single episode of WD-PR. Sodium intake decreased Fos-ir in facilitatory areas such as the lamina terminalis (particularly subfornical organ and median preoptic nucleus), central amygdala and hypothalamic parvocellular paraventricular nucleus in the forebrain. Sodium intake also decreased Fos-ir in inhibitory areas such as the area postrema, lateral parabrachial nucleus and nucleus of the solitary tract in the hindbrain. In contrast, sodium intake further increased Fos-ir that was activated by water deprivation in the dorsal raphe nucleus, another inhibitory area localized in the hindbrain. WD-PR increased Fos-ir in the core and shell of the nucleus accumbens. Sodium intake reduced Fos-ir in both parts of the accumbens. In summary, sodium intake following WD-PR reduced Fos-ir in most facilitatory and inhibitory areas, but increased Fos-ir in another inhibitory area. It also reduced Fos-ir in a reward area (accumbens). The results suggest a functional link between sodium intake and the activity of the hindbrain-forebrain circuitry subserving reward and sodium appetite in response to water deprivation.en
dc.description.affiliationInstituto de Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina
dc.description.affiliationDepartment of Physiology, School of Medicine, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil
dc.description.affiliationDepartment of Physiology and Pathology, School of Dentistry, Universidade Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil
dc.description.affiliationUnespDepartment of Physiology and Pathology, School of Dentistry, Universidade Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
dc.description.sponsorshipSecretaría de Ciencia y Tecnología (SECyT)
dc.description.sponsorshipMinisterio de Ciencia, Tecnología e Innovación Productiva (Mincyt)
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT)
dc.description.sponsorshipIdCNPq: 301296/2009-0
dc.description.sponsorshipIdFAPESP-PRONEX: 2011/50770-1
dc.description.sponsorshipIdCONICET: PIP 2013-2015
dc.description.sponsorshipIdSECyT: PID 2014-2015
dc.description.sponsorshipIdMincyt: PID 116-2010
dc.description.sponsorshipIdANPCyT: PICT 2010-2072
dc.format.extent494-501
dc.identifierhttp://dx.doi.org/10.1016/j.physbeh.2015.08.020
dc.identifier.citationPhysiology & Behavior, v. 151, p. 494-501, 2015.
dc.identifier.doi10.1016/j.physbeh.2015.08.020
dc.identifier.issn1873-507X
dc.identifier.pubmed26297688
dc.identifier.urihttp://hdl.handle.net/11449/131680
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofPhysiology & Behavior
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectAngiotensin iien
dc.subjectRewarden
dc.subjectSatietyen
dc.subjectSodium appetiteen
dc.subjectThirsten
dc.subjectWater intakeen
dc.titleMapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: influence of sodium intakeen
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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