Maternal separation on the ethanol-preferring adult rat liver structure

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dc.contributor.authorRosa-Toledo, Olegário [UNESP]
dc.contributor.authorAlmeida-Chuffa, Luiz G. [UNESP]
dc.contributor.authorMartinez, Marcelo
dc.contributor.authorFelipe-Pinheiro, Patricia F. [UNESP]
dc.contributor.authorPadovani, Carlos R. [UNESP]
dc.contributor.authorMartinez, Francisco E. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2015-12-07T15:32:41Z
dc.date.available2015-12-07T15:32:41Z
dc.date.issued2015
dc.description.abstractBackground and rationale for the study. We designed to test whether there is interaction of maternal separation (MS) on the ethanol-preferring rats liver structure. The UCh rat pups were separated daily from their mothers during the stress hyporesponsive period (SHRP), between four and 14 days-old, always at the same time for four hours in a cage containing eight subdivisions, one for each pup. Subsequently, rats that presented the highest (UChB) and the lowest (UChA) ethanol (EtOH) consumption were selected to the study. Both UChB and UChA rats received 10% (v/v) EtOH and distilled water ad libitum until the end of the experiment (120 days-old). The liver was collected to histological routine for morphometric and stereological analyses, and immunohistochemistry. There was an interaction of MS and EtOH on the liver: increased liver mass, peritubular vessels, stellate cell numbers, steatosis and cell death, decreased necrosis, sinusoidal capillary diameters and cell proliferation. While there was a decrease in FSH, testosterone and 5α-di-hidrotestosterone, and increasing corticosterone and cholesterol. There is interaction of MS and EtOH on the liver structure, dependent on the amount of EtOH intake. Furthermore, the interaction of stress and drugs can increase or decrease their effects on the liver or indirectly via hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes.en
dc.description.affiliationDepartament of Anatomy, Biosciences Institute, State University Julio de Mesquita Filho (UNESP) Botucatu, São Paulo, Brazil
dc.description.affiliationDepartament of Bioestatistic, Biosciences Institute, State University Julio de Mesquita Filho (UNESP) Botucatu, São Paulo, Brazil
dc.description.affiliationDepartament of Morphology and Pathology, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil
dc.description.affiliationUnespDepartament of Anatomy, Biosciences Institute, State University Julio de Mesquita Filho (UNESP) Botucatu, São Paulo, Brazil
dc.description.affiliationUnespDepartament of Bioestatistic, Biosciences Institute, State University Julio de Mesquita Filho (UNESP) Botucatu, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2008/56229-8
dc.format.extent910-918
dc.identifierhttp://dx.doi.org/10.5604/16652681.1171783
dc.identifier.citationAnnals Of Hepatology, v. 14, n. 6, p. 910-918, 2015.
dc.identifier.doi10.5604/16652681.1171783
dc.identifier.issn1665-2681
dc.identifier.pubmed26436364
dc.identifier.urihttp://hdl.handle.net/11449/131216
dc.language.isoeng
dc.relation.ispartofAnnals Of Hepatology
dc.relation.ispartofjcr1.576
dc.relation.ispartofsjr0,640
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.titleMaternal separation on the ethanol-preferring adult rat liver structureen
dc.typeArtigo
unesp.author.lattes8727897080522289[5]
unesp.author.orcid0000-0002-7719-9682[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Anatomia - IBB
Artigos - Bioestatística - IBB