Validation of Fingernail Fluoride Concentration as a Predictor of Risk for Dental Fluorosis

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dc.contributor.authorBuzalaf, M. A. R.
dc.contributor.authorMassaro, C. S.
dc.contributor.authorRodrigues, M. H. C.
dc.contributor.authorFukushima, R.
dc.contributor.authorPessan, Juliano Pelim [UNESP]
dc.contributor.authorWhitford, G. M.
dc.contributor.authorSampaio, F. C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionGeorgia Hlth Sci Univ
dc.date.accessioned2013-09-30T18:30:34Z
dc.date.accessioned2014-05-20T13:44:13Z
dc.date.available2013-09-30T18:30:34Z
dc.date.available2014-05-20T13:44:13Z
dc.date.issued2012-01-01
dc.description.abstractThe aim of this study was to validate the use of fingernail fluoride concentrations at ages 2-7 years as predictors of the risk for developing dental fluorosis in the permanent dentition. Fifty-six children of both genders (10-15 years of age) had their incisors and premolars examined for dental fluorosis using the Thylstrup-Fejerskov index. Fingernail fluoride concentrations were obtained from previous studies when children were 2-7 years of age. Data were analyzed by unpaired t test, ANOVA, and Fisher's exact test when the fingernail fluoride concentrations were dichotomized (<= 2 or > 2 mu g/g). Children with dental fluorosis had significantly higher fingernail fluoride concentrations than those without the condition, and the concentrations tended to increase with the severity of fluorosis (r(2) = 0.47, p < 0.0001). Using a fingernail fluoride concentration of 2 mu g/g at ages 2-7 years as a threshold, this biomarker had high sensitivity (0.84) and moderate specificity (0.53) as a predictor for dental fluorosis. The high positive predictive value indicates that fingernail fluoride concentrations should be useful in public health research, since it has the potential to identify around 80% of children at risk of developing dental fluorosis. Copyright (C) 2012 S. Karger AG, Baselen
dc.description.affiliationUniv São Paulo, Dept Biol Sci, Bauru Dent Sch, BR-17012901 Bauru, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Aracatuba Dent Sch, Dept Pediat Dent & Publ Hlth, Aracatuba, Brazil
dc.description.affiliationUniversidade Federal da Paraíba (UFPB), Hlth Sci Ctr, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationGeorgia Hlth Sci Univ, Dept Oral Biol, Augusta, GA USA
dc.description.affiliationUnespSão Paulo State Univ, Aracatuba Dent Sch, Dept Pediat Dent & Publ Hlth, Aracatuba, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 576703/2008-7
dc.description.sponsorshipIdFAPESP: 01/00237-3
dc.description.sponsorshipIdFAPESP: 02/07875-8
dc.format.extent394-400
dc.identifierhttp://dx.doi.org/10.1159/000339088
dc.identifier.citationCaries Research. Basel: Karger, v. 46, n. 4, p. 394-400, 2012.
dc.identifier.doi10.1159/000339088
dc.identifier.issn0008-6568
dc.identifier.urihttp://hdl.handle.net/11449/15485
dc.identifier.wosWOS:000305636200008
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofCaries Research
dc.relation.ispartofjcr2.188
dc.relation.ispartofsjr1,108
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBiomarkeren
dc.subjectDental fluorosisen
dc.subjectFingernailen
dc.subjectFluorideen
dc.titleValidation of Fingernail Fluoride Concentration as a Predictor of Risk for Dental Fluorosisen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Journal/Guidelines/238704#15
dcterms.rightsHolderKarger
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Odontologia Infantil e Social - FOA