Semisolid systems containing propolis for the treatment of periodontal disease: In vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties

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dc.contributor.authorBruschi, Marcos L.
dc.contributor.authorJones, David S.
dc.contributor.authorPanzeri, Heitor
dc.contributor.authorGremião, Maria Palmira Daflon [UNESP]
dc.contributor.authorDe Freitas, Osvaldo
dc.contributor.authorLara, Elza H. G.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionQueens Univ Belfast
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:31Z
dc.date.available2014-05-20T13:24:31Z
dc.date.issued2007-08-01
dc.description.abstractFormulations containing poloxamer 407 (P407), carbopol 934P (C934P), and propolis extract (PE) were designed for the treatment of periodontal disease. Gelation temperature, in vitro drug release, rheology, hardness, compressibility, adhesiveness, mucoadhesion, and syringeability of formulations were determined. Propolis release from formulations was controlled by the phenomenon of relaxation of polymer chains. Formulations exhibited pseudoplastic flow and low degrees of thixotropy or rheopexy. In most samples, increasing the concentration of C934P content significantly increased storage modulus (G'), loss modulus (G ''), and dynamic viscosity (n') at 5 degrees C, G '' exceeded G'. At 25 and 37 degrees C, n' of each formulation depended on the oscillatory frequency. Formulations showed thermoresponsive behavior, existing as a liquid at room temperature and gel at 34-37 degrees C. Increasing the C934P content or temperature significantly increased formulation hardness, compressibility, and adhesiveness. The greatest mucoadhesion was noted in the formulation containing 15% P407 (w/w) and 0.25% C934P (w/w). The work of syringeability values of all formulations were similar and very desirable with regard to ease of administration. The data obtained in these formulations indicate a potentially useful role in the treatment of periodontitis and suggest they are worthy of clinical evaluation. (c) 2007 Wiley-Liss, Inc.en
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, Programa Posgrad Ciências Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationQueens Univ Belfast, Ctr Med Biol, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland
dc.description.affiliationUniv São Paulo, Fac Odontol, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, Araraquara, SP, Brazil
dc.format.extent2074-2089
dc.identifierhttp://dx.doi.org/10.1002/jps.20843
dc.identifier.citationJournal of Pharmaceutical Sciences. Hoboken: John Wiley & Sons Inc., v. 96, n. 8, p. 2074-2089, 2007.
dc.identifier.doi10.1002/jps.20843
dc.identifier.issn0022-3549
dc.identifier.urihttp://hdl.handle.net/11449/7632
dc.identifier.wosWOS:000248427900018
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Pharmaceutical Sciences
dc.relation.ispartofjcr3.075
dc.relation.ispartofsjr0,984
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbiodegradable polymerspt
dc.subjectbuccalpt
dc.subjectnatural productspt
dc.subjectmechanical propertiespt
dc.subjectinjectablespt
dc.subjecthydrogelspt
dc.subjectoral drug deliverypt
dc.titleSemisolid systems containing propolis for the treatment of periodontal disease: In vitro release kinetics, syringeability, rheological, textural, and mucoadhesive propertiesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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