Cardiac hypertrophy and structural and metabolic remodeling related to seasonal dormancy in the first annual cycle in tegu lizards

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dc.contributor.authorSilveira, Lilian Cristina da
dc.contributor.authorNascimento, Lucas Francisco R. do
dc.contributor.authorColquhoun, Alison
dc.contributor.authorAbe, Augusto S. [UNESP]
dc.contributor.authorSouza, Silvia Cristina R. de
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:04Z
dc.date.available2014-12-03T13:11:04Z
dc.date.issued2013-07-01
dc.description.abstractMorpho-functional adjustments in the heart of juvenile tegu lizards (Tupinambis merianae) were analyzed at distinct seasonal periods to investigate how the demands of growth and of energy saving are reconciled during the first annual cycle. The relative ventricular mass (Mv) was 31% and 69% larger in late autumn and winter dormancy, respectively, compared to early autumn. This effect did not persist during unfed arousal, suggesting that protein accumulates in the heart during hypometabolism and is degraded on arousal. Both the hypertrophy and the atrophy were disproportionate in the largest individuals. In contrast, Mv was smaller in lizards that were starved during spring activity compared to fed lizards, this effect being larger in smaller individuals. In late autumn and winter dormancy the spongy myocardium had 8% of the section area covered by lacunary spaces, which expanded after food intake during arousal and reached 29% in spring activity together with higher density of cardiomyocytes. Total and soluble proteins per mass unity were unchanged, and maximum activities of selected enzymes suggest sustained glycolytic and aerobic capacities during hypometabolism. Results indicate that important structural adjustments occur in the heart in anticipation of dormancy, and that the protein balance in the tissue is maintained at winter temperatures similar to 17 degrees C. (c) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Dept Physiol, Inst Biosci, BR-05508900 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Cellular & Dev Biol, Inst Biomed Sci, BR-05508900 Sao Paulo, Brazil
dc.description.affiliationState Univ Sao Paulo, Dept Zool, Inst Biosci, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespState Univ Sao Paulo, Dept Zool, Inst Biosci, BR-13506900 Rio Claro, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent371-380
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2013.04.006
dc.identifier.citationComparative Biochemistry And Physiology A-molecular & Integrative Physiology. New York: Elsevier Science Inc, v. 165, n. 3, p. 371-380, 2013.
dc.identifier.doi10.1016/j.cbpa.2013.04.006
dc.identifier.issn1095-6433
dc.identifier.urihttp://hdl.handle.net/11449/112815
dc.identifier.wosWOS:000320685800009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Biochemistry and Physiology A-molecular & Integrative Physiology
dc.relation.ispartofjcr2.258
dc.relation.ispartofsjr0,836
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMetabolismen
dc.subjectCardiac hypertrophyen
dc.subjectSeasonal dormancyen
dc.subjectMyocardiumen
dc.subjectTupinambis merianaeen
dc.titleCardiac hypertrophy and structural and metabolic remodeling related to seasonal dormancy in the first annual cycle in tegu lizardsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes8776757457144680[4]
unesp.author.orcid0000-0002-0691-2364[3]
unesp.author.orcid0000-0002-6765-8726[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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