GnRH agonist versus GnRH antagonist in poor ovarian responders: A meta-analysis

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dc.contributor.authorFranco, J. G.
dc.contributor.authorBaruffi, R. L R
dc.contributor.authorMauri, A. L. [UNESP]
dc.contributor.authorPetersen, C. G. [UNESP]
dc.contributor.authorFelipe, V.
dc.contributor.authorCornicelli, J.
dc.contributor.authorCavagna, M.
dc.contributor.authorOliveira, J. B A
dc.contributor.institutionCentre for Human Reproduction Prof. Franco Junior
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSanto Amaro University
dc.date.accessioned2014-05-27T11:22:01Z
dc.date.available2014-05-27T11:22:01Z
dc.date.issued2006-11-01
dc.description.abstractThe aim of this meta-analysis was to compare the efficacy of gonadotrophin antagonist (GnRH-ant) versus GnRH agonist (GnRHa) as coadjuvant therapy for ovarian stimulation in poor ovarian responders in IVF/intracytoplasmic sperm injection cycles. Search strategies included on-line surveys of databases such as MEDLINE, EMBASE and others. A fixed effects model was used for odds ratio (OR) and effect size (weighted mean difference, WMD). Six trials fulfilled the inclusion criteria (randomized controlled trials). There was no difference between GnRH-ant and GnRHa (long and flare-up protocols) with respect to cycle cancellation rate, number of mature oocytes and clinical pregnancy rate per cycle initiated, per oocyte retrieval and per embryo transfer. When the mete-analysis was applied to the two trials that had used GnRH-ant versus long protocols of GnRHa, a significantly higher number of retrieved oocytes was observed in the GnRH-ant protocols [P = 0.018; WMD: 1.12 (0.18, 2.05)]. However, when the meta-analysis was applied to the four trials that had used GnRH-ant versus flare-up protocols, a significantly higher number of retrieved oocytes (P = 0.032; WMD: -0.51, 95% CI -0.99, -0.04) was observed in the GnRHa protocols. Nevertheless, additional randomized controlled trials with better planning are needed to confirm these results.en
dc.description.affiliationCentre for Human Reproduction Prof. Franco Junior, Av. Prof. João Fiusa 689, 14025-310 Ribeirão Preto
dc.description.affiliationDepartment of Gynecology and Obstetrics Faculty of Medicine of Botucatu UNESP, Botucatu
dc.description.affiliationFaculty of Medicine Santo Amaro University, São Paulo, SP
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics Faculty of Medicine of Botucatu UNESP, Botucatu
dc.format.extent618-627
dc.identifierhttp://dx.doi.org/10.1016/S1472-6483(10)60651-7
dc.identifier.citationReproductive BioMedicine Online, v. 13, n. 5, p. 618-627, 2006.
dc.identifier.doi10.1016/S1472-6483(10)60651-7
dc.identifier.issn1472-6483
dc.identifier.scopus2-s2.0-33751111752
dc.identifier.urihttp://hdl.handle.net/11449/69186
dc.identifier.wosWOS:000241921100002
dc.language.isoeng
dc.relation.ispartofReproductive BioMedicine Online
dc.relation.ispartofjcr2.967
dc.relation.ispartofsjr1,343
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectGnRH agonist
dc.subjectGnRH antagonist
dc.subjectOvarian
dc.subjectPoor responder
dc.subjectStimulation
dc.subjectbuserelin acetate
dc.subjectcetrorelix
dc.subjectchorionic gonadotropin
dc.subjectethinylestradiol plus levonorgestrel
dc.subjectganirelix
dc.subjectgonadorelin agonist
dc.subjectgonadorelin antagonist
dc.subjecthuman menopausal gonadotropin
dc.subjectleuprorelin
dc.subjectnordett
dc.subjectrecombinant follitropin
dc.subjecttriptorelin
dc.subjecturofollitropin
dc.subjectadjuvant therapy
dc.subjectclinical protocol
dc.subjectclinical trial
dc.subjectdata base
dc.subjectdrug efficacy
dc.subjectdrug response
dc.subjecteffect size
dc.subjectEMBASE
dc.subjectembryo transfer
dc.subjectfertilization in vitro
dc.subjecthuman
dc.subjectinfertility therapy
dc.subjectinformation retrieval
dc.subjectintracytoplasmic sperm injection
dc.subjectMEDLINE
dc.subjectmeta analysis
dc.subjectonline system
dc.subjectoocyte maturation
dc.subjectovary hyperstimulation
dc.subjectpregnancy rate
dc.subjectrisk assessment
dc.subjectstatistical analysis
dc.subjectsystematic review
dc.subjectDrug Administration Schedule
dc.subjectFemale
dc.subjectFertility Agents, Female
dc.subjectFertilization in Vitro
dc.subjectGonadotropin-Releasing Hormone
dc.subjectHumans
dc.subjectInfertility, Female
dc.subjectOdds Ratio
dc.subjectOvulation Induction
dc.subjectRandomized Controlled Trials
dc.subjectTreatment Outcome
dc.titleGnRH agonist versus GnRH antagonist in poor ovarian responders: A meta-analysisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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