Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

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dc.contributor.authorVillaboim de Castro Lima, Carlos Eugenio
dc.contributor.authorCalixto, Jimmy Cavalcanti
dc.contributor.authorAnbinder, Ana Lia [UNESP]
dc.contributor.institutionUNITAU Univ Taubate
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:30Z
dc.date.available2014-05-20T14:04:30Z
dc.date.issued2011-01-01
dc.description.abstractSimvastatin, a drug used to lower blood cholesterol, has been reported to have an anabolic effect on bone. The purpose of this study was to evaluate the influence of simvastatin and demineralized bovine bone matrix (DBBM) on the repair of rat calvarial defects. Defects of 5 mm were created in 64 rats, divided into four groups: no local treatment (control); treatment with DBBM (DBBM); treatment with a combination of simvastatin solution (2.2 mg/50 mu l) and DBBM (DBBMSIM-1); and treatment with simvastatin solution (0.5 mg/50 mu l) and DBBM (DBBMSIM-2). Animals were sacrificed on postoperative day 30 or 60, after which the calvariae were X-rayed and prepared for histomorphometric evaluation. The data were submitted to statistical analysis (p < 0.05). Xrays revealed that, on postoperative day 30, animals treated with a lower dose of simvastatin presented the lowest bone density, whereas on postoperative day 60 the use of simvastatin, regardless of the dose, resulted in lower density than that observed in control and DBBM group samples. Histomorphometric analysis revealed that, on postoperative day 30, both DBBM and DBBMSIM-1 had a negative impact on bone formation. on postoperative day 60, none of the combinations tested impaired bone repair. These results showed that the association between DBBM and simvastatin had a negative impact on bone repair.en
dc.description.affiliationUNITAU Univ Taubate, Dept Dent, Taubate, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Sao Jose dos Campos Sch Dent, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Sao Jose dos Campos Sch Dent, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/55508-8
dc.format.extent42-48
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242011000100008
dc.identifier.citationBrazilian Oral Research. São Paulo: Sociedade Brasileira de Pesquisa Odontologica, v. 25, n. 1, p. 42-48, 2011.
dc.identifier.fileS1806-83242011000100008.pdf
dc.identifier.issn1806-8324
dc.identifier.lattes6097967943008273
dc.identifier.orcid0000-0003-3930-4274
dc.identifier.scieloS1806-83242011000100008
dc.identifier.urihttp://hdl.handle.net/11449/22632
dc.identifier.wosWOS:000311654700008
dc.language.isoeng
dc.publisherSociedade Brasileira de Pesquisa Odontológica (SBPqO)
dc.relation.ispartofBrazilian Oral Research
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectSimvastatinen
dc.subjectBone Regenerationen
dc.subjectBone Matrixen
dc.titleInfluence of the association between simvastatin and demineralized bovine bone matrix on bone repair in ratsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bor/paboutj.htm
dcterms.rightsHolderSociedade Brasileira de Pesquisa Odontologica
unesp.author.lattes6097967943008273[3]
unesp.author.orcid0000-0003-3930-4274[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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Artigos - Biociências e Diagnóstico Bucal - ICT