Efeitos do alopurinol em rins isquemicos de caes anestesiados com pentobarbital sodico

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dc.contributor.authorMódolo, Norma Sueli Pinheiro [UNESP]
dc.contributor.authorCastiglia, Yara Marcondes Machado [UNESP]
dc.contributor.authorGanem, Eliana Marisa [UNESP]
dc.contributor.authorBraz, José Reinaldo Cerqueira [UNESP]
dc.contributor.authorVianna, Pedro Thadeu Galvão [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:52Z
dc.date.available2014-05-27T11:19:52Z
dc.date.issued2000-01-01
dc.description.abstractBackground and Objectives - Allopurinol is a drug which inhibits the formation of noxious renal free radicals. The aim of this study was to evaluate the protecting renal effects of allopurinol in ischemic kidneys of dogs. Methods - Sixteen dogs were anesthetized with sodium pentobarbital and submitted to extracellular volume expansion (1.4 ml.kg-1.min-1), to mechanic ventilation with air, to right nephrectomy and to left renal artery clamping. Changes which might occur in renal morphology and function after 30 min of total ischemia and posterior reperfusion were studied in Group 1 (G1), in addition to the action of allopurinol (50 mg.kg-1) on those kidneys, when administered 24 h before the experiment and 1 h before the ischemic procedure in Group 2 (G2). The following parameters: heart rate, inferior vena cava pressure, mean blood pressure, PAH clearance (PAH(c)), renal blood flow (RBF), renal vascular resistance (RVR), creatinine clearance (Cr(c)), filtration fraction, urine output, plasma and urine osmolality, osmolar clearance, free water, sodium and potassium clearance, urine and fractional sodium and potassium excretion, hematocrit, rectal temperature, and left kidney histology were evaluated in four moments: M1 control, and M2, M3, M4 obtained immediately, 15 and 30 min after unclamping of the left renal artery. In G2, M1, M2, M3 and M4 were obtained 45, 90, 105, and 120 min after the second allopurinol dose. Results - Both groups showed the highest values for PAH(c), RBF, and Cr(c), and the lowest values for RVR in M1. Animals were tachycardiac since the beginning of the experiment both in G1 and in G2. The other parameters were not changed. Left kidney histological evaluation showed alterations compatible with acute tubular necrosis in both experimental groups. Conclusions - Alterations found in renal hemodynamics were compatible with the release of vasoconstrictor substances due to renal ischemia. Allopurinol was not effective in preventing renal alterations caused by ischemia and reperfusion.en
dc.description.affiliationDept. de Anestesiologia da FMB UNESP, Distrito de Rubiao Junior, 18618-970 Botucatu, SP
dc.description.affiliationUnespDept. de Anestesiologia da FMB UNESP, Distrito de Rubiao Junior, 18618-970 Botucatu, SP
dc.format.extent239-245
dc.identifierhttp://www.sba.com.br/arquivos/revista/rba/mai00239.pdf
dc.identifier.citationRevista Brasileira de Anestesiologia, v. 50, n. 3, p. 239-245, 2000.
dc.identifier.file2-s2.0-0034083388.pdf
dc.identifier.issn0034-7094
dc.identifier.lattes8223546475724058
dc.identifier.lattes8226942130768820
dc.identifier.scopus2-s2.0-0034083388
dc.identifier.urihttp://hdl.handle.net/11449/66071
dc.language.isopor
dc.relation.ispartofRevista Brasileira de Anestesiologia
dc.relation.ispartofjcr0.850
dc.relation.ispartofsjr0,320
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectANIMAL: dog
dc.subjectCOMPLICATIONS: renal ischemia
dc.subjectDRUGS: allopurinol
dc.subjectHYPNOTICS, Barbiturate: pentobarbital
dc.subjectallopurinol
dc.subjectcreatinine
dc.subjectpentobarbital
dc.subjectpotassium
dc.subjectsodium
dc.subjectanesthesia
dc.subjectanimal experiment
dc.subjectartery clamp
dc.subjectcontrolled study
dc.subjectdog
dc.subjectdrug effect
dc.subjectfemale
dc.subjecthematocrit
dc.subjecthemodynamics
dc.subjectkidney clearance
dc.subjectkidney ischemia
dc.subjectkidney perfusion
dc.subjectmale
dc.subjectnephrectomy
dc.subjectnonhuman
dc.subjectplasma osmolality
dc.subjecturine osmolality
dc.subjecturine volume
dc.titleEfeitos do alopurinol em rins isquemicos de caes anestesiados com pentobarbital sodicopt
dc.title.alternativeEffects of allopurinol in ischemic kidneys of dogs anesthetized with sodium pentobarbitalen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rba/paboutj.htm
unesp.author.lattes8223546475724058
unesp.author.lattes8226942130768820
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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