Strength training and growth hormone: effects on bone of Wistar rats

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dc.contributor.authorCastoldi, Robson Chacon [UNESP]
dc.contributor.authorGiometti, Ines Cristina
dc.contributor.authorOzaki, Guilherme Akio Tamura
dc.contributor.authorGarcia, Thiago Alves
dc.contributor.authorUeno, Melise Jacon Peres [UNESP]
dc.contributor.authorFernandes, Fernanda [UNESP]
dc.contributor.authorDornelles, Rita Cássia Menegati [UNESP]
dc.contributor.authorLouzada, Mario Jefferson Quirino
dc.contributor.authorFilho, José Carlos Silva Camargo [UNESP]
dc.contributor.authorBelangero, William Dias
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUNOESTE
dc.contributor.institutionCatholic Salesian Auxilium University Centre
dc.date.accessioned2021-06-25T11:01:57Z
dc.date.available2021-06-25T11:01:57Z
dc.date.issued2021-01-01
dc.description.abstractIntroduction: The use of growth hormone (GH) in several sports has also been observed, becoming a problem for antidoping control agencies in the high-performance sports environment. In addition, the use of this substance may pose a risk, expose users to potential health problems and bone alterations. Objective: The objective of the present study was to verify the effects of muscular strength training and application of a GH protocol on mineral density, bone strength, and trabecular tissue. Methods: 40 Wistar rats, 60 days old, were used. The animals were divided into four groups: control (C), control and application of GH (GHC), muscular strength training (T), and muscular strength training with the application of GH (GHT). Animals of the GHC and GHT groups received administration of 0.2 IU/kg of GH prior to perform the T protocol. The animals of the T and GHT groups performed four series of 10 jumps, 3×/week, for 4/weeks. The values of bone mineral density (BMD), bone strength (F-max), and Micro Computed Tomography (MCT) were obtained. Results: An increase in the BMD variable was observed in all experimental groups (C = 0.110 ± 0.005; GHC = 0.134 ± 0.05; T = 0.127 ± 0.004; GHT = 0.133 ± 0.008 g/cm2) (C vs GHT p < 0.05). No statistical difference was observed for the F-max variable. For MCT, all experimental groups presented an increase in the number of trabeculae (Tb.N) (C = 1.10 ± 0.22; GHC = 1.79 ± 0.07; T = 1.91 ± 0.04; GHT = 1.91 ± 0.09) (p < 0.05). Conclusion: It was concluded that both GH and T were able to promote increases in BMD and Tb.N; however, no significant difference was observed for the F-max.en
dc.description.affiliationDepartment of Physical Therapy Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESP
dc.description.affiliationDepartment Orthopedic and Traumatology Universidade Estadual de Campinas UNICAMP
dc.description.affiliationFaculty of Veterinary Medicine Universidade do Oeste Paulista UNOESTE
dc.description.affiliationDepartment of Animal Support Production and Health Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESP
dc.description.affiliationDepartment of Basic Sciences Araçatuba Dental School Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESP
dc.description.affiliationCatholic Salesian Auxilium University Centre
dc.description.affiliationLaboratório de Análise da Plasticidade Muscular LAPMUS UNESP/FCT Campus de Presidente Prudente, Rua Roberto Simonsen, 305, Bairro: Centro Educacional
dc.description.affiliationUnespDepartment of Physical Therapy Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESP
dc.description.affiliationUnespDepartment of Animal Support Production and Health Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESP
dc.description.affiliationUnespDepartment of Basic Sciences Araçatuba Dental School Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESP
dc.description.affiliationUnespLaboratório de Análise da Plasticidade Muscular LAPMUS UNESP/FCT Campus de Presidente Prudente, Rua Roberto Simonsen, 305, Bairro: Centro Educacional
dc.identifierhttp://dx.doi.org/10.1007/s11332-021-00784-1
dc.identifier.citationSport Sciences for Health.
dc.identifier.doi10.1007/s11332-021-00784-1
dc.identifier.issn1825-1234
dc.identifier.issn1824-7490
dc.identifier.scopus2-s2.0-85107465288
dc.identifier.urihttp://hdl.handle.net/11449/207843
dc.language.isoeng
dc.relation.ispartofSport Sciences for Health
dc.sourceScopus
dc.subjectAnabolics
dc.subjectBone mineral density
dc.subjectBone strength
dc.subjectMicrostructure trabecular
dc.subjectPhysical training
dc.titleStrength training and growth hormone: effects on bone of Wistar ratsen
dc.typeArtigo
unesp.author.orcid0000-0002-4167-6790[1]

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