Successful immunotherapy in a murine metastasizing fibrosarcoma model

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dc.contributor.authorCortes, Ruben [UNESP]
dc.contributor.authorCorrea, Luis A. [UNESP]
dc.contributor.authorBehbehani, Abdulla I. [UNESP]
dc.contributor.authorSonis, Stephen T. [UNESP]
dc.contributor.authorWilson, Richard E. [UNESP]
dc.contributor.institutionInstituto Nacional de la Nutriclon
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:53:45Z
dc.date.available2022-04-28T19:53:45Z
dc.date.issued1984-01-01
dc.description.abstractAntigenic differences were demonstrated between the primary murine fibrosarcoma and its metastases. Immunization with irradiated primary tumor cells (TC) protected C57B1/6J mice against subsequent challenge with those cells, but not against challenge with cells from pulmonary metastases (PMC). Mice immunized with irradiated PMC were protected from challenge with those cells, but not against challenge with TC. Mice with fibrosarcomas produced by the injection of 5 × 103 cells from the primary tumor were treated by resection of the tumor‐bearing limb (Amp), Amp plus cylcophosphamide (Amp+Cy), Amp plus primary TC (Amp+TC), Amp plus primary TC and from its metastatic variant (Amp + TC + PMC), and with combinations of the last two groups with Cy. Although Amp+Cy improved survival, no animal lived 100 days and metastases increased as compared to controls. Immunotherapy significantly improved survival and decreased pulmonary metastases. Antigen combinations from primary and metastatic tumors resulted in significantly better survival than did a single preparation only from TC. Chemotherapy did not enhance the results obtained with immunotherapy and surgery. Immunity conferred in long‐term survivors was permanent. Copyright © 1984 Wiley‐Liss, Inc., A Wiley Companyen
dc.description.affiliationDepartment of Surgery Brigham and Women's Hospital Instituto Nacional de la Nutriclon, Mexico
dc.description.affiliationDepartamento de Urologia Faculdade de Medicina de Botucatu-UNESP, Sao Paulo
dc.description.affiliationUnespDepartamento de Urologia Faculdade de Medicina de Botucatu-UNESP, Sao Paulo
dc.format.extent289-295
dc.identifierhttp://dx.doi.org/10.1002/jso.2930250415
dc.identifier.citationJournal of Surgical Oncology, v. 25, n. 4, p. 289-295, 1984.
dc.identifier.doi10.1002/jso.2930250415
dc.identifier.issn1096-9098
dc.identifier.issn0022-4790
dc.identifier.scopus2-s2.0-0021260806
dc.identifier.urihttp://hdl.handle.net/11449/223904
dc.language.isoeng
dc.relation.ispartofJournal of Surgical Oncology
dc.sourceScopus
dc.subjectantigen
dc.subjectfibrosarcoma
dc.subjectimmunotherapy
dc.subjectmurine
dc.titleSuccessful immunotherapy in a murine metastasizing fibrosarcoma modelen
dc.typeArtigo

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