Respiratory chemoreceptor function in vertebrates - Comparative and evolutionary aspects

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dc.contributor.authorSundin, Lena
dc.contributor.authorBurleson, Mark L.
dc.contributor.authorSanchez, Adriana P.
dc.contributor.authorAmin-Naves, Jalile
dc.contributor.authorKinkead, Richard
dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.authorHartzler, Lynn K.
dc.contributor.authorWiemann, Martin
dc.contributor.authorKumar, Prem
dc.contributor.authorGlass, Mogens L.
dc.contributor.institutionBox 463
dc.contributor.institutionUniversity of North Texas
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionLaval University
dc.contributor.institutionCanada Research Department of Respiratory Neurobiology
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBoonshoft School of Medicine
dc.contributor.institutionUniversity Duisburg
dc.contributor.institutionUniversity of Birmingham
dc.date.accessioned2014-05-27T11:22:36Z
dc.date.available2014-05-27T11:22:36Z
dc.date.issued2007-10-01
dc.description.abstractThe sensing of blood gas tensions and/or pH is an evolutionarily conserved, homeostatic mechanism, observable in almost all species studied from invertebrates to man. In vertebrates, a shift from the peripheral O2-oriented sensing in fish, to the central CO2/pH sensing in most tetrapods reflects the specific behavioral requirements of these two groups whereby, in teleost fish, a highly O2-oriented control of breathing matches the ever-changing and low oxygen levels in water, whilst the transition to air-breathing increased the importance of acid-base regulation and O2-related drive, although retained, became relatively less important. The South American lungfish and tetrapods are probably sister groups, a conclusion backed up by many similar features of respiratory control. For example, the relative roles of peripheral and central chemoreceptors are present both in the lungfish and in land vertebrates. In both groups, the central CO2/pH receptors dominate the ventilatory response to hypercarbia (60-80), while the peripheral CO2/pH receptors account for 20-30. Some basic components of respiratory control have changed little during evolution. This review presents studies that reflect the current trends in the field of chemoreceptor function, and several laboratories are involved. An exhaustive review on the previous literature, however, is beyond the intended scope of the article. Rather, we present examples of current trends in respiratory function in vertebrates, ranging from fish to humans, and focus on both O2 sensing and CO2 sensing. As well, we consider the impact of chronic levels of hypoxia - a physiological condition in fish and in land vertebrates resident at high elevations or suffering from one of the many cardiorespiratory disease states that predispose an animal to impaired ventilation or cardiac output. This provides a basis for a comparative physiology that is informative about the evolution of respiratory functions in vertebrates and about human disease. Currently, most detail is known for mammals, for which molecular biology and respiratory physiology have combined in the discovery of the mechanisms underlying the responses of respiratory chemoreceptors. Our review includes new data on nonmammalian vertebrates, which stresses that some chemoreceptor sites are of ancient origin.en
dc.description.affiliationDepartment of Zoophysiology Göteborg University Box 463, SE-405 30 Göteborg
dc.description.affiliationDepartment of Biological Sciences University of North Texas, PO Box 305220, Denton, TX 76203-5220
dc.description.affiliationDepartment of Physiology Faculty of Medicine of Ribeirão Preto University of São Paulo, Avenida Bandeirantes 3.900, Ribeirão Preto, SP
dc.description.affiliationDepartment of Pediatrics Laval University
dc.description.affiliationCanada Research Department of Respiratory Neurobiology
dc.description.affiliationDepartment of Animal Morphology and Physiology São Paulo State University - FCAV, Jaboticabal, SP
dc.description.affiliationDepartment of Neuroscience, Cell Biology, and Physiology Wright State University Boonshoft School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435
dc.description.affiliationInstitute of Physiology University Duisburg, Essen Hufelandstr
dc.description.affiliationDepartment of Physiology Medical School University of Birmingham, B15 2TT
dc.description.affiliationUnespDepartment of Animal Morphology and Physiology São Paulo State University - FCAV, Jaboticabal, SP
dc.format.extent592-600
dc.identifierhttp://dx.doi.org/10.1093/icb/icm076
dc.identifier.citationIntegrative and Comparative Biology, v. 47, n. 4, p. 592-600, 2007.
dc.identifier.doi10.1093/icb/icm076
dc.identifier.issn1540-7063
dc.identifier.issn1557-7023
dc.identifier.scopus2-s2.0-38749134550
dc.identifier.urihttp://hdl.handle.net/11449/69902
dc.language.isoeng
dc.relation.ispartofIntegrative and Comparative Biology
dc.relation.ispartofjcr2.751
dc.relation.ispartofsjr1,319
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnimalia
dc.subjectInvertebrata
dc.subjectLepidosirenidae
dc.subjectMammalia
dc.subjectTeleostei
dc.subjectTetrapoda
dc.subjectVertebrata
dc.titleRespiratory chemoreceptor function in vertebrates - Comparative and evolutionary aspectsen
dc.typeArtigo
dcterms.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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