Efeito sinérgico entre a dexmedetomidina e a ropivacaína 0,75% na anestesia peridural

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dc.contributor.authorSalgado, Paula Fialho Saraiva
dc.contributor.authorSabbag, Amália Tieco
dc.contributor.authorDa Silva, Priscila Costa
dc.contributor.authorBrienze, Sergio Luís Aparecido
dc.contributor.authorDalto, Helio Pontes
dc.contributor.authorMódolo, Norma Sueli Pinheiro [UNESP]
dc.contributor.authorBraz, José Reinaldo Cerqueira [UNESP]
dc.contributor.authorNascimento Junior, Paulo do [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:49Z
dc.date.available2014-05-27T11:22:49Z
dc.date.issued2008-03-01
dc.description.abstractBACKGROUND. This study aimed to evaluate clinical characteristics of epidural anesthesia performed with 0.75% ropivacaine associated with dexmedetomidine. METHODS. Forty patients scheduled for hernia repair or varicose vein surgeries under epidural anesthesia participated in this study. They were assigned to: Control Group (n = 20), 0.75% ropivacaine, 20 ml (150 mg); and Dexmedetomidine Group (n = 20), 0.75% ropivacaine, 20 ml (150 mg), plus dexmedetomidine, 1 μg.kg -1. The following variables were studied: total analgesic block onset time, upper level of analgesia, analgesic and motor block duration time, intensity of motor block, state of consciousness, hemodynamics, postoperative analgesia and incidence of side-effects. RESULTS. Epidural dexmedetomidine did not affect onset time or upper level of anesthesia (p > 0.05) however it prolonged sensory and motor block duration time (p < 0.05) and postoperative analgesia (p < 0.05), and also resulted in a more intense motor block, 1 (p < 0.05). Values of bispectral index were lower in Dexmedetomidine Group (p < 0.05). There was no difference in incidence of hypotension and bradycardia (p > 0.05). Occurrence of side-effects (shivering, vomiting and SpO 2 < 90%) was low and similar between groups (p > 0.05). CONCLUSION. There is clear synergism between epidural dexmedetomidine and ropivacaine, further this drug association does not bring about additional morbidity.en
dc.description.affiliationDepartamento de Anestesiologia Faculdade de Medicina de Botucatu, Distrito de Rubião Jr, s/n - Caixa Postal 530, Botucatu - SP Cep 18618-970
dc.description.affiliationUnespDepartamento de Anestesiologia Faculdade de Medicina de Botucatu, Distrito de Rubião Jr, s/n - Caixa Postal 530, Botucatu - SP Cep 18618-970
dc.format.extent110-115
dc.identifierhttp://dx.doi.org/10.1590/S0104-42302008000200011
dc.identifier.citationRevista da Associacao Medica Brasileira, v. 54, n. 2, p. 110-115, 2008.
dc.identifier.doi10.1590/S0104-42302008000200011
dc.identifier.file2-s2.0-45849096058.pdf
dc.identifier.issn0104-4230
dc.identifier.lattes8223546475724058
dc.identifier.lattes8745358989680600
dc.identifier.orcid0000-0002-2323-9159
dc.identifier.scieloS0104-42302008000200011
dc.identifier.scopus2-s2.0-45849096058
dc.identifier.urihttp://hdl.handle.net/11449/70329
dc.language.isopor
dc.relation.ispartofRevista da Associação Médica Brasileira
dc.relation.ispartofjcr0.736
dc.relation.ispartofsjr0,265
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnalgesics
dc.subjectAnesthetic techniques
dc.subjectAnesthetics
dc.subjectDexmedetomidine
dc.subjectEpidural block
dc.subjectRopivacaine
dc.subjectalpha adrenergic receptor stimulating agent
dc.subjectamide
dc.subjectdexmedetomidine
dc.subjectlocal anesthetic agent
dc.subjectropivacaine
dc.subjectadolescent
dc.subjectadult
dc.subjectchi square distribution
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdouble blind procedure
dc.subjectdrug potentiation
dc.subjectepidural anesthesia
dc.subjectfemale
dc.subjecthuman
dc.subjectinguinal hernia
dc.subjectleg
dc.subjectmale
dc.subjectmiddle aged
dc.subjectnerve block
dc.subjectnonparametric test
dc.subjectrandomized controlled trial
dc.subjecttime
dc.subjectAdolescent
dc.subjectAdrenergic alpha-Agonists
dc.subjectAdult
dc.subjectAmides
dc.subjectAnesthesia, Epidural
dc.subjectAnesthetics, Local
dc.subjectChi-Square Distribution
dc.subjectDouble-Blind Method
dc.subjectDrug Synergism
dc.subjectFemale
dc.subjectHernia, Inguinal
dc.subjectHumans
dc.subjectLower Extremity
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNerve Block
dc.subjectStatistics, Nonparametric
dc.subjectTime Factors
dc.subjectYoung Adult
dc.titleEfeito sinérgico entre a dexmedetomidina e a ropivacaína 0,75% na anestesia periduralpt
dc.title.alternativeSynergistic effect between dexmedetomidine and 0.75% ropivacaine in epidural anesthesiaen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/ramb/paboutj.htm#03
unesp.author.lattes8223546475724058
unesp.author.lattes8745358989680600[8]
unesp.author.orcid0000-0002-2323-9159[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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