Photodynamic therapy for the treatment of induced mammary tumor in rats

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dc.contributor.authorFerreira, Isabelle [UNESP]
dc.contributor.authorFerreira, Juliana
dc.contributor.authorVollet-Filho, José Dirceu
dc.contributor.authorMoriyama, Lilian T.
dc.contributor.authorBagnato, Vanderlei S.
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorRocha, Noeme Sousa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Do Vale Do Paraíba (UNIVAP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:28:17Z
dc.date.available2014-05-27T11:28:17Z
dc.date.issued2013-02-01
dc.description.abstractThe objective of this work was to evaluate photodynamic therapy (PDT) by using a hematoporphyrin derivative as a photosensitizer and light-emitting diodes (LEDs) as light source in induced mammary tumors of Sprague-Dawley (SD) rats. Twenty SD rats with mammary tumors induced by DMBA were used. Animals were divided into four groups: control (G1), PDT only (G2), surgical removal of tumor (G3), and submitted to PDT immediately after surgical removal of tumor (G4). Tumors were measured over 6 weeks. Lesions and surgical were LEDs lighted up (200 J/cm2 dose). The light distribution in vivo study used two additional animals without mammary tumors. In the control group, the average growth of tumor diameter was approximately 0.40 cm/week. While for PDT group, a growth of less than 0.15 cm/week was observed, suggesting significant delay in tumor growth. Therefore, only partial irradiation of the tumors occurred with a reduction in development, but without elimination. Animals in G4 had no tumor recurrence during the 12 weeks, after chemical induction, when compared with G3 animals that showed 60 % recurrence rate after 12 weeks of chemical induction. PDT used in the experimental model of mammary tumor as a single therapy was effective in reducing tumor development, so the surgery associated with PDT is a safe and efficient destruction of residual tumor, preventing recurrence of the tumor. © 2012 Springer-Verlag London Ltd.en
dc.description.affiliationFaculdade de Medicina Veterinária e Zootecnia Departamento de Clínica Veterinária Universidade Estadual Paulista (UNESP), São Paulo
dc.description.affiliationInstituto de Pesquisa e Desenvolvimento Universidade Do Vale Do Paraíba (UNIVAP), São José dos Campos, São Paulo
dc.description.affiliationDepartamento de Física e Ciência Dos Materiais Laboratório de Biofotônica Universidade de São Paulo (USP), São Paulo
dc.description.affiliationFaculdade de Medicina Departamento Patologia Universidade Estadual Paulista (UNESP), São Paulo
dc.description.affiliationUnespFaculdade de Medicina Veterinária e Zootecnia Departamento de Clínica Veterinária Universidade Estadual Paulista (UNESP), São Paulo
dc.description.affiliationUnespFaculdade de Medicina Departamento Patologia Universidade Estadual Paulista (UNESP), São Paulo
dc.format.extent571-577
dc.identifierhttp://dx.doi.org/10.1007/s10103-012-1114-3
dc.identifier.citationLasers in Medical Science, v. 28, n. 2, p. 571-577, 2013.
dc.identifier.doi10.1007/s10103-012-1114-3
dc.identifier.issn0268-8921
dc.identifier.issn1435-604X
dc.identifier.lattes5051118752980903
dc.identifier.lattes6077735918469284
dc.identifier.orcid0000-0002-8188-8149
dc.identifier.scopus2-s2.0-84879693590
dc.identifier.urihttp://hdl.handle.net/11449/74452
dc.identifier.wosWOS:000315579400029
dc.language.isoeng
dc.relation.ispartofLasers in Medical Science
dc.relation.ispartofjcr1.949
dc.relation.ispartofsjr0,713
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAdjuvant therapy
dc.subjectComet assay
dc.subjectMammary tumors
dc.subjectPDT
dc.subjecthematoporphyrin derivative
dc.subjectphotogem
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbreast surgery
dc.subjectbreast tumor
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjectin vivo study
dc.subjectlight emitting diode
dc.subjectnonhuman
dc.subjectphotodynamic therapy
dc.subjectpriority journal
dc.subjectrat
dc.subjectrecurrence risk
dc.subjecttumor growth
dc.subjecttumor recurrence
dc.subjecttumor volume
dc.titlePhotodynamic therapy for the treatment of induced mammary tumor in ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.author.lattes5051118752980903
unesp.author.lattes6077735918469284[7]
unesp.author.orcid0000-0002-8188-8149[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Clínica Veterinária - FMVZ
Artigos - Patologia - FMB