Estudo das propriedades analgésicas da Achillea millefolium L. (Asteraceae)

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dc.contributor.authorMistieri, M. L A [UNESP]
dc.contributor.authorThomazo, N. M M [UNESP]
dc.contributor.authorMataqueiro, M. I. [UNESP]
dc.contributor.authorQueiroz-Neto, A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:17Z
dc.date.available2014-05-27T11:20:17Z
dc.date.issued2001-07-05
dc.description.abstractThis study was designed to separately evaluate the analgesic capacity of 15% tea from Achillea millefolium leaves and florid ends. Three different tests were performed. The animals were separated in 3 groups: group I (control) that received water, group II that received florid end tea, and group III that received leaf tea. The first test was the writhing test induced by intraperitoneal injection of acetic acid in male Swiss mice. The second test consisted of the measurement of tail flick reflex latency (TFRL) in male Wistar rats after receiving a painful thermal stimulus. The groups received the teas or water per os, prior to observation. In the third test, the Wistar rats were submitted to an approximately 1 cm long incision in their tails to test the effect of the teas on induced inflammatory pain. The results showed that the effect of the 15% leaf tea on the mice writhing and TFRL test were not statistically significant. The florid ends tea showed a significantly increase in number of writhes in mice and TFRL in rats after administration. With regard to the effect of the teas on inflammatory pain, ingestion of both preparations caused an increase in the force threshold necessary for the avoidance reflex, indicating antihyperalgesic action of both the leaf and florid ends 15% teas of Achillea millefolium.en
dc.description.affiliationLab. Farmacol. Toxicol. Faculdade UNESP Câmpus de Jaboticabal, Via Acesso Paulo Donato Castellane, 14884-900 Jaboticabal
dc.description.affiliationUnespLab. Farmacol. Toxicol. Faculdade UNESP Câmpus de Jaboticabal, Via Acesso Paulo Donato Castellane, 14884-900 Jaboticabal
dc.format.extent1-6
dc.identifierhttp://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo_1_v3_n2.pdf
dc.identifier.citationRevista Brasileira de Plantas Medicinais, v. 3, n. 2, p. 1-6, 2001.
dc.identifier.file2-s2.0-0034967462.pdf
dc.identifier.issn1516-0572
dc.identifier.scopus2-s2.0-0034967462
dc.identifier.urihttp://hdl.handle.net/11449/66549
dc.language.isopor
dc.relation.ispartofRevista Brasileira de Plantas Medicinais
dc.relation.ispartofsjr0,199
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnalgesics non-narcotic
dc.subjectAsteraceae
dc.subjectHyperalgesia
dc.subjectMillefolium
dc.subjectacetic acid
dc.subjectAchillea extract
dc.subjectanalgesic agent
dc.subjectunclassified drug
dc.subjectAchillea
dc.subjectanalgesic activity
dc.subjectanimal experiment
dc.subjectcontrolled study
dc.subjectinflammation
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectmouse strain
dc.subjectnonhuman
dc.subjectpain
dc.subjectplant leaf
dc.subjectrat
dc.subjecttail flick test
dc.subjecttea
dc.subjectthermal stimulation
dc.subjectwrithing test
dc.subjectAchillea millefolium
dc.subjectAnimalia
dc.subjectRattus norvegicus
dc.titleEstudo das propriedades analgésicas da Achillea millefolium L. (Asteraceae)pt
dc.title.alternativeStudy of the analgesic properties of the Achillea millefolium (Asteraceae)en
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rbpm/paboutj.htm#03
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR