Increased glucose synthesis in renal tubule fragments from hyperthyroid rats

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dc.contributor.authorPimenta, W. P. [UNESP]
dc.contributor.authorSilva Veiga, J. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:54:51Z
dc.date.available2022-04-28T19:54:51Z
dc.date.issued1999-01-01
dc.description.abstractRates of glucose synthesis from several substrates were examined in renal tubule fragments from hyperthyroid rats. A hyperthyroid state was induced by daily intraperitoneal injections of thyroxine (T4) (100 μg/100 g body weight) for 14 days. At the end of the experimental period, plasma triiodothyronine and T4 levels were six and eight times higher, respectively, than initial values. Hyperthyroid rats gained less weight and had lower blood glucose despite an increased food intake. In both control and hyperthyroid rats, rates of glucose production by renal tubule fragments were higher with glutamine and glycerol than with lactate, alanine, or glutamate. T4 treatment induced a significant increase in the de novo glucose synthesis from all substrates, except glutamine. The highest percent increase was obtained with alanine (64%), compared with 31-40% for glutamate, lactate, and glycerol. The T4 treatment induced increase in glucose synthesis by renal tubule fragments suggests that renal gluconeogenesis contributes to enhance glucose production in hyperthyroidism.en
dc.description.affiliationDepartamento de Fisiologia Instituto de Biociencias UNESP, 18618-000 Botucatu, SP
dc.description.affiliationDepartamento de Clinica Medica Faculdade de Medicina Universidade Estadual Paulista, 18618-000 Botucatu, SP
dc.description.affiliationUnespDepartamento de Fisiologia Instituto de Biociencias UNESP, 18618-000 Botucatu, SP
dc.description.affiliationUnespDepartamento de Clinica Medica Faculdade de Medicina Universidade Estadual Paulista, 18618-000 Botucatu, SP
dc.format.extent143-146
dc.identifierhttp://dx.doi.org/10.1139/y99-006
dc.identifier.citationCanadian Journal of Physiology and Pharmacology, v. 77, n. 2, p. 143-146, 1999.
dc.identifier.doi10.1139/y99-006
dc.identifier.issn0008-4212
dc.identifier.scopus2-s2.0-0032798815
dc.identifier.urihttp://hdl.handle.net/11449/224121
dc.language.isoeng
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.sourceScopus
dc.subjectAlanine
dc.subjectGlutamate
dc.subjectGlutamine
dc.subjectGlycerol
dc.subjectHyperthyroidism
dc.subjectLactate
dc.subjectRat
dc.subjectRenal gluconeogenesis
dc.subjectRenal tubule fragments
dc.titleIncreased glucose synthesis in renal tubule fragments from hyperthyroid ratsen
dc.typeArtigo

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