Evaluation of pulsed electromagnetic field protocols in implant osseointegration: in vivo and in vitro study

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dc.contributor.authorNunes, Camilla Magnoni Moretto [UNESP]
dc.contributor.authorFerreira, Camila Lopes [UNESP]
dc.contributor.authorBernardo, Daniella Vicensotto [UNESP]
dc.contributor.authorLopes, Cássia Carolina Rabelo [UNESP]
dc.contributor.authorCollino, Luma [UNESP]
dc.contributor.authorda Silva Lima, Victória Clara [UNESP]
dc.contributor.authorde Camargo Reis Mello, Daphne [UNESP]
dc.contributor.authorde Vasconcellos, Luana Marotta Reis [UNESP]
dc.contributor.authorJardini, Maria Aparecida Neves [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T11:05:18Z
dc.date.available2021-06-25T11:05:18Z
dc.date.issued2021-05-01
dc.description.abstractObjectives: The present study aims to evaluate two protocols of pulsed electromagnetic field (PEMF) on osseointegration and establish one that addresses ideal parameters for its use in dentistry, especially in the optimization of the implants osseointegration process. Materials and methods: Sixty male rats (Wistar) were allocated into three experimental groups: control (GC), test A (GTA, 3 h exposed), and test B (GTB, 1 h exposed). All animals received titanium implants in both tibias, and PEMF application (15 Hz, ± 1 mT, 5 days/week) occurred only in the test groups. They were euthanized at 03, 07, 21, and 45 days after PEMF therapy. Removal torque, histomorphometric measurements, three-dimensional radiographic evaluation, and in vitro biological assay analyses were performed. Results: GTB showed better results compared with GTA in removal torque tests, in bone volume and bone mineral density, cell viability, total protein content, and mineralization nodules (p < 0.05). GTA showed better performance in trabecular bone thickness and cell proliferation compared with GTB (p < 0.05), especially at osseointegration early periods. In the histomorphometric analysis and number of trabeculae, there were no differences in the test groups. Conclusion: PEMF as a biostimulator was effective in optimizing the events in bone tissue that lead to osseointegration, especially when applied for a shorter time and in the initial periods of bone healing. Clinical relevance: The PEMF therapy is an effective alternative method for optimizing bone healing.en
dc.description.affiliationDepartment of Diagnosis and Surgery São Paulo State University (UNESP) Institute of Science and Technology of São José dos Campos, Av Engenheiro Francisco José Longo, 777, São Dimas
dc.description.affiliationDepartment of Bioscience and Bucal Diagnosis São Paulo State University (UNESP) Institute of Science and Technology of São José dos Campos
dc.description.affiliationUnespDepartment of Diagnosis and Surgery São Paulo State University (UNESP) Institute of Science and Technology of São José dos Campos, Av Engenheiro Francisco José Longo, 777, São Dimas
dc.description.affiliationUnespDepartment of Bioscience and Bucal Diagnosis São Paulo State University (UNESP) Institute of Science and Technology of São José dos Campos
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2018/13942-8
dc.description.sponsorshipIdFAPESP: 2019/01669-8
dc.description.sponsorshipIdCNPq: CNPq – 465259/2014-6
dc.format.extent2925-2937
dc.identifierhttp://dx.doi.org/10.1007/s00784-020-03612-x
dc.identifier.citationClinical Oral Investigations, v. 25, n. 5, p. 2925-2937, 2021.
dc.identifier.doi10.1007/s00784-020-03612-x
dc.identifier.issn1436-3771
dc.identifier.issn1432-6981
dc.identifier.scopus2-s2.0-85092380811
dc.identifier.urihttp://hdl.handle.net/11449/208036
dc.language.isoeng
dc.relation.ispartofClinical Oral Investigations
dc.sourceScopus
dc.subjectBone-anchored implants
dc.subjectElectromagnetic fields
dc.subjectOsseointegration
dc.subjectRats
dc.titleEvaluation of pulsed electromagnetic field protocols in implant osseointegration: in vivo and in vitro studyen
dc.typeArtigo
unesp.author.orcid0000-0003-3229-8019[9]

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Artigos - Biociências e Diagnóstico Bucal - ICT
Artigos - Diagnóstico e Cirurgia - ICT