Effects of chronic experimental alcoholism on the epithelium of the uterine horn of rats (Rattus norvegicus albinus)

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dc.contributor.authorMartinez, Marcelo
dc.contributor.authorGarcia, P. J.
dc.contributor.authorCagnon, V. H. A.
dc.contributor.authorMello Júnior, Wílson de [UNESP]
dc.contributor.authorPadovani, C. R.
dc.contributor.authorMartinez, F. E.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-27T11:20:14Z
dc.date.available2014-05-27T11:20:14Z
dc.date.issued2001-01-01
dc.description.abstractSixty adult tats (Rattus norvegicus albinus) of the same age (3 months) and with a mean body weight of 228 g were divided into two experimental groups. The control group received solid diet (Purina rat chow) and tap water ad libitum. The other (alcoholic group), received the same solid diet and was allowed to drink only sugar cane brandy dissolved in 30° Gay Lussac (v/v). At the end of periods of 90, 180 and 270 days of treatment, the animals were anaesthetized with ethyl ether during estrus, weighed and sacrificed. The final mean body weights were similar in the control and alcoholic groups. The results showed intense atrophy on the lining epithelium of the endometrium of uterine horns in the alcoholic group. Important ultrastructural epithelial alterations were also observed in the female alcoholic group, such as: intense lipid droplet accumulation, increased rough endoplasmic reticulum cisternae and mitochondrial size and presence of intraepithelial neutrophils. The secretory activity of these rats was reduced. Therefore, we concluded that alcohol acts as a toxin on the epithelial layer of the rat endometrium.en
dc.description.affiliationDept. of Morphology and Pathology Fed. University of São Carlos, São Paulo
dc.description.affiliationDepartment of Anatomy State University of São Paulo, São Paulo
dc.description.affiliationDepartment of Biostatistics State University of São Paulo, São Paulo
dc.description.affiliationDepartment of Anatomy University of Campinas, São Paulo
dc.description.affiliationDepto. de Morfologia e Patologia Univ. Federal de São Carlos, Via Washington Luis Km 235 s/no, CEP 13.565.905, São Carlos, SP
dc.format.extent107-115
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11686391
dc.identifier.citationJournal of Submicroscopic Cytology and Pathology, v. 33, n. 1-2, p. 107-115, 2001.
dc.identifier.issn1122-9497
dc.identifier.lattes8727897080522289
dc.identifier.lattes1739564105219382
dc.identifier.scopus2-s2.0-0035225743
dc.identifier.urihttp://hdl.handle.net/11449/66446
dc.language.isoeng
dc.relation.ispartofJournal of Submicroscopic Cytology and Pathology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAlcoholism
dc.subjectEpithelium
dc.subjectRats
dc.subjectUterine horns
dc.subjectalcoholic beverage
dc.subjectalcoholism
dc.subjectanimal
dc.subjectatrophy
dc.subjectbody weight
dc.subjectcell organelle
dc.subjectchemically induced disorder
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectelectron microscopy
dc.subjectepithelium
dc.subjectfemale
dc.subjectpathology
dc.subjectrat
dc.subjectrat strain
dc.subjecttime
dc.subjectultrastructure
dc.subjectuterus
dc.subjectAlcoholic Beverages
dc.subjectAnimals
dc.subjectAtrophy
dc.subjectBody Weight
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectMicroscopy, Electron
dc.subjectOrganelles
dc.subjectRats, Inbred Strains
dc.subjectTime Factors
dc.subjectUterus
dc.titleEffects of chronic experimental alcoholism on the epithelium of the uterine horn of rats (Rattus norvegicus albinus)en
dc.typeArtigo
unesp.author.lattes8727897080522289[5]
unesp.author.lattes1739564105219382
unesp.author.orcid0000-0002-7719-9682[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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