Increases in placental nitric oxide, but not nitric oxide-mediated relaxation, underlie the improvement in placental efficiency and antihypertensive effects of hydrogen sulphide donor in hypertensive pregnancy

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dc.contributor.authorPossomato-Vieira, Jose S. [UNESP]
dc.contributor.authorChimini, Jessica S. [UNESP]
dc.contributor.authorda Silva, Maria L. S. [UNESP]
dc.contributor.authorDias-Junior, Carlos A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:01:59Z
dc.date.available2019-10-06T16:01:59Z
dc.date.issued2018-11-01
dc.description.abstractDysregulation of hydrogen sulphide (H2S) producing enzymes has been related to hypertensive pregnancy, and H2S donor, sodium hydrosulphide (NaHS) exerts antihypertensive effects, modulates angiogenic factors production and acts as an antioxidant. Moreover, reduction in nitric oxide (NO) bioavailability is related to hypertensive pregnancy and H2S may interact with NO, modulating its production. We aimed to investigate the NaHS effects in hypertension-in-pregnancy and also in feto-placental parameters. Female Wistar rats (200-250 g) were mated and desoxycorticosterone acetate injections followed by replacement of water by 0.9% saline solution were used to induce hypertensive pregnancy. Rats were divided into four groups: normal pregnant (Norm-Preg), pregnant + NaHS (Preg+NaHS), hypertensive pregnant (HTN-Preg) and HTN-Preg+NaHS. Systolic blood pressure was increased in HTN-Preg and this increase was blunted in HTN-Preg+NaHS. Fetal and placental weights were decreased in HTN-Preg animals, while fetal growth restriction was improved in HTN-Preg+NaHS. Placental weight was lower in HTN-Preg+NaHS than in HTN-Preg; however, placental efficiency was re-established in HTN-Preg+NaHS rats. We observed that a partial contribution of placental NO, but not changes in anti-angiogenic factors may mediate the increases in placental efficiency in HTN-Preg+NaHS. HTN-Preg presented thoracic aorta hyperreactivity to phenylephrine while NaHS treatment blunted this hyperreactivity, which seems not to be related to NO-mediated relaxation induced by acetylcholine. Therefore, changes in vascular responsiveness promoted by NaHS treatment may underlie the beneficial effects in systolic blood pressure and feto-placental parameters in our study.en
dc.description.affiliationDepartment of Pharmacology Biosciences Institute of Botucatu São Paulo State University – UNESP
dc.description.affiliationUnespDepartment of Pharmacology Biosciences Institute of Botucatu São Paulo State University – UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2016/18782-3
dc.format.extent1118-1127
dc.identifierhttp://dx.doi.org/10.1111/1440-1681.13000
dc.identifier.citationClinical and Experimental Pharmacology and Physiology, v. 45, n. 11, p. 1118-1127, 2018.
dc.identifier.doi10.1111/1440-1681.13000
dc.identifier.issn1440-1681
dc.identifier.issn0305-1870
dc.identifier.scopus2-s2.0-85055354749
dc.identifier.urihttp://hdl.handle.net/11449/188248
dc.language.isoeng
dc.relation.ispartofClinical and Experimental Pharmacology and Physiology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjecthydrogen sulphide
dc.subjecthypertenstion in pregnancy
dc.subjectnitric oxide
dc.subjectvascular reactivity
dc.titleIncreases in placental nitric oxide, but not nitric oxide-mediated relaxation, underlie the improvement in placental efficiency and antihypertensive effects of hydrogen sulphide donor in hypertensive pregnancyen
dc.typeArtigo
unesp.author.lattes6296664642422599[4]
unesp.author.orcid0000-0002-0348-6144[4]

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