New methodologies for old problems: Tridimensional gastrointestinal organoids and guts-on-a-chip

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dc.contributor.authorSakalem, Marna Eliana [UNESP]
dc.contributor.authorRibeiro-Paes, João Tadeu [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:52:23Z
dc.date.available2018-12-11T16:52:23Z
dc.date.issued2018-01-01
dc.description.abstractObjectives: The present review intended to present a critical overview of the methodological and experimental advances concerning tridimensional cell culture models within the scope of gastrointestinal research. Methods: A literature review was performed and some of the main published articles in the area were mentioned. Main results: Classic studies and high impact results were presented, starting from the pioneer works with gastrointestinal organoids, with a small gut organoid, to the achievement of guts-on-a-chip and multi-organ-chips. It was also discussed which implications the construction of such co-cultures bring, as well as future applications arising from these new methodologies. Conclusions: Despite the still discrete number of publications, in quantitative terms, there are qualitative promising and consistent results addressing physiopathological aspects and new therapeutic perspectives of tridimensional in vitro cultures in the gastroenterology field. It is expected, thus, that such new methodological approaches, including organoids and guts-on-a-chip, may contribute decisively to the advance in knowledge on basic aspects, as well as on the translation to new therapeutic approaches in gastrointestinal diseases.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Laboratório de Genética e Terapia Celular (GenTe Cel)
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Laboratório de Genética e Terapia Celular (GenTe Cel)
dc.format.extent90-93
dc.identifierhttp://dx.doi.org/10.1016/j.jcol.2017.10.002
dc.identifier.citationJournal of Coloproctology, v. 38, n. 1, p. 90-93, 2018.
dc.identifier.doi10.1016/j.jcol.2017.10.002
dc.identifier.file2-s2.0-85043760183.pdf
dc.identifier.issn2237-9363
dc.identifier.scopus2-s2.0-85043760183
dc.identifier.urihttp://hdl.handle.net/11449/170781
dc.language.isoeng
dc.relation.ispartofJournal of Coloproctology
dc.relation.ispartofsjr0,167
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectGastrointestinal
dc.subjectGut-on-a-chip
dc.subjectIn vitro tridimensional models
dc.subjectOrganoids
dc.subjectOrgans-on-a-chip
dc.titleNew methodologies for old problems: Tridimensional gastrointestinal organoids and guts-on-a-chipen
dc.titleNovas metodologias para velhos problemas: Organoides gastrointestinais e guts-on-a-chip tridimensionaispt
dc.typeResenha

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