Effects of beta-aminopropionitrile fumarate and exercise on equine tendon healing: Gross and histological aspects

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dc.contributor.authorAlves, Ana Liz Garcia [UNESP]
dc.contributor.authorRodrigues, MAM
dc.contributor.authorAguiar, AJA
dc.contributor.authorThomassian, A.
dc.contributor.authorNicoletti, JLM
dc.contributor.authorHussni, Carlos Alberto [UNESP]
dc.contributor.authorBorges, Alexandre Secorun [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:31:53Z
dc.date.available2014-05-20T13:31:53Z
dc.date.issued2001-07-01
dc.description.abstractIn the present study, the effects of intralesional injections of beta-aminopropionitrile fumarate (BAPN-F) was assessed in equine experimental tendinitis. BAPN-F is a lathyrogen which inhibits crosslinking of collagen, permitting more time for parallel reorientation of the repair tissue. Sixteen two-year-old Arabian horses without health problems were used in this experiment. The animals were divided into two groups: group one was left in box rest, and group two was submitted to controlled exercise during the experiment. Tendinitis was induced with collagenase in the superficial flexor tendon of both forelimbs. Twenty days after the induction of tendinitis, intralesional treatment with BAPN-F was performed and the contralateral limbs received saline. A biopsy was obtained and gross and histopathological analysis was performed on the 150th day of the experiment. The collagen fibrillar alignment pattern in the heating area was better in the BAPN-F group submitted to controlled exercise than in the other group, as observed by sonographic and histopathologic examination. The present results indicate that BAPN-F in combination with controlled loading improved sear remodeling and tendon wound collagen maturation.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, FMVZ, Dept Vet Surg & Anesthesiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, FM, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dept Clin Sci, Aracatuba, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, FMVZ, Dept Vet Surg & Anesthesiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, FM, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Clin Sci, Aracatuba, Brazil
dc.format.extent335-340
dc.identifierhttp://dx.doi.org/10.1016/S0737-0806(01)70076-7
dc.identifier.citationJournal of Equine Veterinary Science. Wildomar: William E Jones Dvm, v. 21, n. 7, p. 335-340, 2001.
dc.identifier.doi10.1016/S0737-0806(01)70076-7
dc.identifier.issn0737-0806
dc.identifier.lattes7773733250141398
dc.identifier.lattes6020984937849801
dc.identifier.lattes9643433706163946
dc.identifier.lattes7162819131462797
dc.identifier.urihttp://hdl.handle.net/11449/10872
dc.identifier.wosWOS:000170434000011
dc.language.isoeng
dc.publisherWilliam E Jones Dvm
dc.relation.ispartofJournal of Equine Veterinary Science
dc.relation.ispartofjcr0.880
dc.relation.ispartofsjr0,390
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleEffects of beta-aminopropionitrile fumarate and exercise on equine tendon healing: Gross and histological aspectsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderWilliam E Jones Dvm
unesp.author.lattes7773733250141398[1]
unesp.author.lattes6020984937849801[6]
unesp.author.lattes9643433706163946[7]
unesp.author.lattes7162819131462797
unesp.author.orcid0000-0001-6256-8089[7]
unesp.author.orcid0000-0001-9092-7819[1]
unesp.author.orcid0000-0001-5421-2904[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Cirurgia e Anestesiologia Veterinária - FMVZ
Artigos - Patologia - FMB