Involvement of GABA(A)-benzodiazepine receptor in the anxiolytic effect induced by hexanic fraction of Rubus brasiliensis

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dc.contributor.authorNogueira, E.
dc.contributor.authorRosa, GJM
dc.contributor.authorVassilieff, V. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:55Z
dc.date.available2014-05-20T13:35:55Z
dc.date.issued1998-06-01
dc.description.abstractTo investigate the ability of hexanic ethanolic fraction of Rubus brasiliensis Martius (Roseceae), to induce anxiolytic effect and also the possible involvement of the GABA(A)-benzodiazepine receptor complex, male Wistar rats and Swiss mice behaviour were tested in the elevated plus maze (EPM). All the doses of the extract, 50, 100 and 150 mg/kg, administered per gavage (vo), 30 min before the behavioural evaluation, induced an anxiolytic effect expressed by: increased number of entries in and time spent in the open arms and percentage of open arm entries: and decreased number of entries and time spent in the closed arms. The treatment of mice with flumazenil (Ro 15-1788), 0.5, 1.0 and 1.5 mg/kg, i.p., 15-min before the administration of hexanic fraction, 100 mg/kg, vo, blocked the hexanic fraction-induced anxiolytic effect. The LD50 for the hexanic fraction was 1512 mg/kg. In conclusion, it was shown that the hexanic fraction of R. brasiliensis induced an anxiolytic effect in rats and mice. This effect can be attributed to a liposoluble principle with low toxicity which may be acting as an agonist on GABA(A)-benzodiazepine receptor complex. (C) 1998 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.description.affiliationUNESP, Biosci Inst, Dept Pharmacol, Neuropharmacol Lab, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Biosci Inst, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Dept Pharmacol, Neuropharmacol Lab, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.format.extent119-126
dc.identifierhttp://dx.doi.org/10.1016/S0378-8741(98)00023-3
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 61, n. 2, p. 119-126, 1998.
dc.identifier.doi10.1016/S0378-8741(98)00023-3
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/11449/12359
dc.identifier.wosWOS:000074385800004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectRubus brasiliensispt
dc.subjectanxiolytic effectpt
dc.subjectelevated plus mazept
dc.subjectGABA(A)-systempt
dc.subjectbenzodiazepine receptorpt
dc.subjectratspt
dc.subjectmicept
dc.titleInvolvement of GABA(A)-benzodiazepine receptor in the anxiolytic effect induced by hexanic fraction of Rubus brasiliensisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0001-9172-6461[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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