Mitochondrial bioenergy alterations in avian HD11 macrophages infected with infectious bronchitis virus

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dc.contributor.authorda Silva, Sergio E. L.
dc.contributor.authorFerreira, Helena L.
dc.contributor.authorGarcia, Andrea F.
dc.contributor.authorSilva, Felipe E. S. [UNESP]
dc.contributor.authorGameiro, Roberto [UNESP]
dc.contributor.authorFabri, Carolina U. F. [UNESP]
dc.contributor.authorVieira, Dielson S. [UNESP]
dc.contributor.authorCardoso, Tereza C. [UNESP]
dc.contributor.institutionUniversidade Federal Uberlândia (UFU)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniSLESIANO
dc.date.accessioned2018-12-11T16:51:13Z
dc.date.available2018-12-11T16:51:13Z
dc.date.issued2018-04-01
dc.description.abstractTo establish an association between mitochondrial dysfunction and apoptosis following infectious bronchitis virus (IBV) infection, HD11 avian macrophage cells were infected with the Massachusetts 41 (M41) strain. Our results show that the M41 strain of IBV induced cytopathic effects followed by the release of new viral particles. Elevated numbers of apoptotic cells were observed at 24, 48 and 72 h post-infection (p.i.). Viral infection was associated with mitochondrial membrane depolarization and reactive oxygen species (ROS) production at all of the examined timepoints p.i. In summary, IBV M41 replication in infected HD11 macrophages seems to induce mitochondrial bioenergy failure, acting as a respiratory chain uncoupler, without compromising viral replication.en
dc.description.affiliationFaculdade de Medicina Veterinária (FAMEV) Universidade Federal Uberlândia (UFU)
dc.description.affiliationDepartment of Veterinary Medicine FZEA-USP-University of Sao Paulo
dc.description.affiliationCollege of Veterinary Medicine UNESP-University of São Paulo State
dc.description.affiliationCentro Universitário Católico Salesiano Auxilium UniSLESIANO
dc.description.affiliationUnespCollege of Veterinary Medicine UNESP-University of São Paulo State
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/16715-4
dc.format.extent1043-1049
dc.identifierhttp://dx.doi.org/10.1007/s00705-018-3704-2
dc.identifier.citationArchives of Virology, v. 163, n. 4, p. 1043-1049, 2018.
dc.identifier.doi10.1007/s00705-018-3704-2
dc.identifier.file2-s2.0-85040066024.pdf
dc.identifier.issn0304-8608
dc.identifier.scopus2-s2.0-85040066024
dc.identifier.urihttp://hdl.handle.net/11449/170532
dc.language.isoeng
dc.relation.ispartofArchives of Virology
dc.relation.ispartofsjr0,973
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleMitochondrial bioenergy alterations in avian HD11 macrophages infected with infectious bronchitis virusen
dc.typeArtigo

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