Hypothalamic disconnection caudal to paraventricular nucleus affects cardiovascular and drinking responses to central angiotensin II and carbachol

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dc.contributor.authorUrzedo-Rodrigues, Lilia Simone
dc.contributor.authorDepieri, Tatiane
dc.contributor.authorCherobino, Anderson Julio
dc.contributor.authorLopes, Oswaldo U.
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorColombari, Debora S. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:46:15Z
dc.date.available2014-05-20T13:46:15Z
dc.date.issued2011-05-04
dc.description.abstractThe paraventricular nucleus of the hypothalamus (PVN) is an important area of the brain involved in the control of cardiovascular system and fluid-electrolyte balance. In the present study we evaluated the effects of hypothalamic disconnection (HD) caudal to PVN in the pressor and dipsogenic responses induced by intracerebroventricular (icy) injections of angiotensin II (ANG II) or carbachol (cholinergic agonist). Male Holtzman rats (280-320 g) with a stainless steel cannula implanted into the lateral ventricle and submitted to sham or D surgery were used. HD (2 or 15 days) reduced the pressor responses to ANG II (50 ng/1 mu l) icy (8 +/- 3 and 11 +/- 3 mm Hg, respectively, vs. sham: 23 +/- 3 and 21 +/- 2 mm Hg) or carbachol (4 nmol/1 mu l (8 +/- 2 and 21 +/- 3 mm Hg, respectively, vs. sham: 33 +/- 3 and 33 +/- 3 mm Hg), without changing baseline arterial pressure. Acutely (2-4 days), HD also reduced water intake to icy ANG II (3.3 +/- 2.2 vs. sham: 14.2 +/- 3.0 ml/60 min) or carbachol (4.4 +/- 1.8 vs. sham: 11.4 +/- 1.6 ml/60 min); however, chronically (15-17 days), HD produced no change on ANG II-and carbachol-induced water intake, in spite of the increased daily water intake and urinary volume. The results suggest that medial projections caudal to PVN are important for pressor and dipsogenic responses to central angiotensinergic and cholinergic activation. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Fisiol & Patol, Fac Odontol Araraquara,Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Fisiol & Patol, Fac Odontol Araraquara,Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent100-108
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2011.03.021
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1388, p. 100-108, 2011.
dc.identifier.doi10.1016/j.brainres.2011.03.021
dc.identifier.fileWOS000290604400011.pdf
dc.identifier.issn0006-8993
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16341
dc.identifier.wosWOS:000290604400011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBlood pressureen
dc.subjectThirsten
dc.subjectParaventricular nucleus of hypothalamusen
dc.subjectVasopressinen
dc.subjectKnife-cuten
dc.titleHypothalamic disconnection caudal to paraventricular nucleus affects cardiovascular and drinking responses to central angiotensin II and carbacholen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[5]
unesp.author.orcid0000-0003-4331-0271[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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