Paracrine and autocrine factors in the differentiation of the cumulus-oocyte complex

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dc.contributor.authorBuratini, J.
dc.contributor.authorCaixeta, E. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:56:49Z
dc.date.available2015-03-18T15:56:49Z
dc.date.issued2012-07-01
dc.description.abstractA better understanding of the paracrine and autocrine regulatory loops within the cumulus-oocyte complex (COC) is fundamental for the improvement of in vitro maturation (IVM) outcomes in humans and domestic species. This review presents the most important local regulators identified in the COC to date with special attention to those secreted by the oocyte and acting on cumulus cells, as well as their roles in different processes crucial for the successful maturation of the COC. An autocrine regulatory loop mediated by epidermal growth factor-like (EGF-like) peptides in cumulus cells triggers COC maturation. During COC differentiation, oocyte secreted factors (OSFs), particularly members of the transforming growth factor-beta (TGF beta) and fibroblast growth factor (FGF) families, regulate meiotic resumption, cumulus expansion, cumulus metabolism, apoptosis and steroidogenesis.en
dc.description.affiliationSao Paulo State Univ, Dept Physiol, Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Physiol, Inst Biosci, Botucatu, SP, Brazil
dc.format.extent414-419
dc.identifierhttp://www.cbra.org.br/pages/publicacoes/animalreproduction/issues/download/v9n3/pag414-419%20%28AR515%29.pdf
dc.identifier.citationAnimal Reproduction. Belo Horizonte: Brazilian Coll Animal Reproduction, v. 9, n. 3, p. 414-419, 2012.
dc.identifier.fileWOS000322438300037.pdf
dc.identifier.issn1806-9614
dc.identifier.urihttp://hdl.handle.net/11449/117709
dc.identifier.wosWOS:000322438300037
dc.language.isoeng
dc.publisherBrazilian Coll Animal Reproduction
dc.relation.ispartofAnimal Reproduction
dc.relation.ispartofjcr0.991
dc.relation.ispartofsjr0,308
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleParacrine and autocrine factors in the differentiation of the cumulus-oocyte complexen
dc.typeArtigo
dcterms.rightsHolderBrazilian Coll Animal Reproduction
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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