Nitric oxide alterations in cardiovascular system of rats with Parkinsonism induced by 6-OHDA and submitted to previous exercise

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dc.contributor.authorde Jager, Lorena
dc.contributor.authorAmorim, Eric Diego Turossi
dc.contributor.authorLucchetti, Bruno Fernando Cruz
dc.contributor.authorLopes, Fernanda Novi Cortegoso
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorPinge-Filho, Phileno
dc.contributor.authorMartins-Pinge, Marli Cardoso
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:20:00Z
dc.date.available2018-12-11T17:20:00Z
dc.date.issued2018-07-01
dc.description.abstractStudies showed that physical exercise decreases the risk of developing Parkinson's disease (PD) as slowing its progression. Nitric oxide (NO) increases in the substantia nigra pars compacta (SNpc) of individuals with PD. However, no study has evaluated the effects of exercise on peripheral NO levels and its modulatory effects on cardiovascular dysfunctions of subjects with PD. Trained (T) or sedentary (S) animals underwent stereotactic surgery for bilateral 6-hydroxydopamine (6-OHDA) or vehicle microinfusion (Sham group). After 6 days, the animals were catheterized for baseline parameters, followed by inhibition of NOS by Nw-nitro-arginine-methyl ester (L-NAME, 10 mg/kg - i.v.). Nitrite concentration was performed in the aorta, heart, kidney, adrenal and plasma. After exercise, the animals presented resting bradycardia (6-OHDA T and Sham T). NO was increased in the aorta of 6-OHDA S, and decreased in 6-OHDA T animals. In the heart, NO was increased in Sham T compared to sedentary and decreased in 6-OHDA T relative to 6-OHDA S and Sham T animals. At the kidney, NO decrease in 6-OHDA S and Sham T when compared to Sham S and, in adrenal gland, there was a decrease in 6-OHDA T in relation to 6-OHDA S. L-NAME promoted lower increases in MAP in 6-OHDA groups. The decreases of HR were enhanced due to physical training. 6-OHDA S group presented decreased systolic arterial pressure variability, not altered by exercise. Our data showed alterations in peripheral NO in the association of exercise with Parkinsonism in the cardiovascular function.en
dc.description.affiliationDepartamento de Ciências Fisiológicas Universidade Estadual de Londrina – UEL
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Araraquara Departamento de Princípios Ativos Naturais e Toxicologia Universidade Estadual Paulista – UNESP
dc.description.affiliationDepartamento de Ciências Patológicas Universidade Estadual de Londrina – UEL
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas de Araraquara Departamento de Princípios Ativos Naturais e Toxicologia Universidade Estadual Paulista – UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCAPES: 1583617
dc.format.extent78-86
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2018.05.017
dc.identifier.citationLife Sciences, v. 204, p. 78-86.
dc.identifier.doi10.1016/j.lfs.2018.05.017
dc.identifier.file2-s2.0-85046741108.pdf
dc.identifier.issn1879-0631
dc.identifier.issn0024-3205
dc.identifier.scopus2-s2.0-85046741108
dc.identifier.urihttp://hdl.handle.net/11449/176298
dc.language.isoeng
dc.relation.ispartofLife Sciences
dc.relation.ispartofsjr1,071
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectArterial pressure
dc.subjectHeart rate
dc.subjectL-NAME
dc.subjectParkinson's disease
dc.subjectSwimming
dc.titleNitric oxide alterations in cardiovascular system of rats with Parkinsonism induced by 6-OHDA and submitted to previous exerciseen
dc.typeArtigo
unesp.author.lattes1117432571971568[5]
unesp.author.orcid0000-0002-9444-1530[7]
unesp.author.orcid0000-0002-1942-858X[5]

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