The anti-ulcerogenic effects of Curatella americana L.

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dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.authorRodrigues, Clenilson Martins [UNESP]
dc.contributor.authorKushima, Helio [UNESP]
dc.contributor.authorMoraes, Thiago Mello [UNESP]
dc.contributor.authorLolis, Solange de Fatima
dc.contributor.authorFeitosa, Shirles Barbosa
dc.contributor.authorMagri, Luciana Pietro
dc.contributor.authorSoares, Fernanda Rocha
dc.contributor.authorCola, Maira Miranda
dc.contributor.authorPezzutto Andrade, Fabio Donizete [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorMonteiro Souza Brito, Alba Regina
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTocantins Fed Univ
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T13:49:31Z
dc.date.available2014-05-20T13:49:31Z
dc.date.issued2009-01-30
dc.description.abstractEthnopharmacological relevance: Curatella americana L. (Dilleneaceae) is a medicinal plant very frequently cited as acting against gastrointestinal disorders in ethnopharmacological inventories of the Cerrado region of Brazil.Aim of the study:The ethanolic extract (CEB)and infusion (BI)of Curatella americana bark were investigated for their ability to prevent and heal ulceration of the gastric mucosa.Materials and methods: The preventive and healing actions of Curatella americana were evaluated in experimental in vivo models in rodents that simulated this disease in human gastric mucosa.Results: CEB significantly decreased the severity of gastric damage formation induced by the combination of several gastroprotective models (HCl/ethanol, indomethacin/bethanecol, absolute ethanol, stress and pylorus ligature). But, unlike CEB, the BI did not exert gastroprotective effect. The gastroprotective action of CEB involved antisecretory action, augmentation of gastric mucus (48%) and participation of endogenous sulfhydryl compounds that increase efficacy of barrier mucosa against injurious agents. CEB also presents effective healing action in chronic gastric disease (1.90 +/- 0.55 vs. 6.86 +/- 0.46 mm(2) in the control) and its action mechanisms consisted of increasing the PGE(2) (40%) and somatostatin levels (269%) while decreasing the gastrin level in rat plasma (79%).Conclusions: The gastroprotective effect and healing action of Curatella americana involved modulation of PGE2, somatostatin and gastrin levels, probably due to the presence of oligomeric and polymeric proanthocyanidins in the bark. (c) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Dept Fisiol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Inst Quim, Dept Quim Organ, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationTocantins Fed Univ, Inst Biol & Saúde Publ, BR-77500000 Porto Nacional, TO, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Fisiol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Quim, Dept Quim Organ, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent425-432
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2008.10.017
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 121, n. 3, p. 425-432, 2009.
dc.identifier.doi10.1016/j.jep.2008.10.017
dc.identifier.issn0378-8741
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/17657
dc.identifier.wosWOS:000263393200011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCuratella americana L.en
dc.subjectDilleneaceaeen
dc.subjectAnti-ulcer actionen
dc.subjectProstaglandin E(2)en
dc.subjectSomatostatinen
dc.subjectGastrinen
dc.titleThe anti-ulcerogenic effects of Curatella americana L.en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3814504901386844[1]
unesp.author.orcid0000-0002-8645-3777[1]
unesp.author.orcid0000-0003-3032-2556[11]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Fisiologia - IBB
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