Red Blood Cell Transfusions are Independently Associated with Intra-Hospital Mortality in Very Low Birth Weight Preterm Infants

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dc.contributor.authorNunes dos Santos, Amelia Miyashiro
dc.contributor.authorGuinsburg, Ruth
dc.contributor.authorBranco de Almeida, Maria Fernanda
dc.contributor.authorProcianoy, Renato S.
dc.contributor.authorLeone, Clea Rodrigues
dc.contributor.authorMartins Marba, Sergio Tadeu
dc.contributor.authorRugolo, Ligia Maria Suppo de Souza [UNESP]
dc.contributor.authorFiori, Humberto Holmer
dc.contributor.authorde Andrade Lopes, Jose Maria
dc.contributor.authorMartinez, Francisco Eulogio
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionPontificia Univ Catolica Rio Grande do Sul
dc.contributor.institutionFundação Oswaldo Cruz
dc.date.accessioned2014-05-20T13:38:01Z
dc.date.available2014-05-20T13:38:01Z
dc.date.issued2011-09-01
dc.description.abstractObjective To test the hypothesis that red blood cell (RBC) transfusions in preterm infants are associated with increased intra-hospital mortality.Study design Variables associated with death were studied with Cox regression analysis in a prospective cohort of preterm infants with birth weight <1500 g in the Brazilian Network on Neonatal Research. Intra-hospital death and death after 28 days of life were analyzed as dependent variables. Independent variables were infant demographic and clinical characteristics and RBC transfusions.Results of 1077 infants, 574 (53.3%) received at least one RBC transfusion during the hospital stay. The mean number of transfusions per infant was 3.3 +/- 3.4, with 2.1 +/- 2.1 in the first 28 days of life. Intra-hospital death occurred in 299 neonates (27.8%), and 60 infants (5.6%) died after 28 days of life. After adjusting for confounders, the relative risk of death during hospital stay was 1.49 in infants who received at least one RBC transfusion in the first 28 days of life, compared with infants who did not receive a transfusion. The risk of death after 28 days of life was 1.89 times higher in infants who received more than two RBC transfusions during their hospital stay, compared with infants who received one or two transfusions.Conclusion Transfusion was associated with increased death, and transfusion guidelines should consider risks and benefits of transfusion. (J Pediatr 2011; 159: 371-6).en
dc.description.affiliationUniv Fed São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniversidade Federal do Rio Grande do Sul (UFRGS), Dept Pediat, Porto Alegre, RS, Brazil
dc.description.affiliationUniv São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Pediat, Campinas, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Pediat, Botucatu, SP, Brazil
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Dept Pediat, Porto Alegre, RS, Brazil
dc.description.affiliationFundação Oswaldo Cruz, Neonatal Dept, Fernandes Figueira Inst, Rio de Janeiro, Brazil
dc.description.affiliationUniv São Paulo, Dept Pediat, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Pediat, Botucatu, SP, Brazil
dc.format.extent371-U220
dc.identifierhttp://dx.doi.org/10.1016/j.jpeds.2011.02.040
dc.identifier.citationJournal of Pediatrics. New York: Mosby-elsevier, v. 159, n. 3, p. 371-U220, 2011.
dc.identifier.doi10.1016/j.jpeds.2011.02.040
dc.identifier.issn0022-3476
dc.identifier.lattes1197755531108177
dc.identifier.urihttp://hdl.handle.net/11449/13183
dc.identifier.wosWOS:000294054200006
dc.language.isoeng
dc.publisherMosby-elsevier
dc.relation.ispartofJournal of Pediatrics
dc.relation.ispartofjcr3.667
dc.relation.ispartofsjr1,522
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleRed Blood Cell Transfusions are Independently Associated with Intra-Hospital Mortality in Very Low Birth Weight Preterm Infantsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderMosby-elsevier
unesp.author.lattes1197755531108177
unesp.author.orcid0000-0002-8407-1556[1]
unesp.author.orcid0000-0001-8297-4164[4]
unesp.author.orcid0000-0002-1550-0740[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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