Correlations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancy

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dc.contributor.authorRezende, Vania B.
dc.contributor.authorBarbosa, Fernando
dc.contributor.authorPalei, Ana C.
dc.contributor.authorCavalli, Ricardo C.
dc.contributor.authorTanus-Santos, Jose E.
dc.contributor.authorSandrim, Valeria Cristina [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-21T20:46:12Z
dc.date.available2015-10-21T20:46:12Z
dc.date.issued2015-01-01
dc.description.abstractAlthough a number of studies have measured circulating levels of some trace elements in preeclampsia (PE) and compared to healthy pregnant (HP), there is no consensus yet about the deficiency of some metals and development of hypertensive disorders in pregnancy. The aim of this study was to compare plasmatic levels of Zn, Mn, Co, Cu, Se and Sr among non-pregnant (NP), healthy pregnant (HP), gestational hypertensive (GH) and preeclamptic (PE) women and to correlate these levels with plasma soluble endoglin (sENG) and soluble fms-like tyrosine kinase-1 (sFLT-1), two important antiangiogenic proteins related to PE. A total of 184 women were enrolled in this study (NP = 35, GH = 51, PE = 37 and HP = 61). Trace element analyses were carried out with an inductively coupled plasma mass spectrometer (ICPMS). sENG and sFLT-1 plasma concentrations were measured by commercial ELISA kits. The most interesting result is that Sr is higher in PE (63%, P<0.001) compared to HP and their levels are positively correlated with sENG in all three groups of pregnant women. Moreover, we found a negative correlation between Zn and sENG in HP (r=-0.43, P=0.003). Regarding other elements, we found similar levels among pregnant groups. In conclusion, this study showed that Sr may has a role in physiopathology of PE. (C) 2014 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Fac Pharmaceut Sci, Dept Clin Toxicol &Bromatol Anal, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Med Sci, Dept Pharmacol, Campinas, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Gynecol &Obstet, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Biosci, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Biosci, Ctr Toxicol Assistance CEATOX, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Inst Biosci, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Inst Biosci, Ctr Toxicol Assistance CEATOX, Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent130-135
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0946672X14001163
dc.identifier.citationJournal Of Trace Elements In Medicine And Biology, v. 29, p. 130-135, 2015.
dc.identifier.doi10.1016/j.jtemb.2014.06.011
dc.identifier.issn0946-672X
dc.identifier.urihttp://hdl.handle.net/11449/129289
dc.identifier.wosWOS:000347498000017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Trace Elements In Medicine And Biology
dc.relation.ispartofjcr3.755
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPreeclampsiaen
dc.subjectTrace elementsen
dc.subjectSren
dc.subjectZnen
dc.subjectsFLT-1en
dc.titleCorrelations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancyen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Botucatu - CEATOX - Centro de Assistência Toxicológica
Artigos - Farmacologia - IBB