Glucose Tolerance and Insulin Action in Monosodium Glutamate (MSG) Obese Exercise-trained Rats

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dc.contributor.authorDe Mello, Maria Alice Rostom [UNESP]
dc.contributor.authorDe Souza, Claudio Teodoro [UNESP]
dc.contributor.authorBraga, Larissa Ribeiro [UNESP]
dc.contributor.authorDos Santos, Júlio Wilson [UNESP]
dc.contributor.authorRibeiro, Inand'Andrea [UNESP]
dc.contributor.authorGobatto, Claudio Alexandre [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:22Z
dc.date.available2014-05-27T11:20:22Z
dc.date.issued2001-12-01
dc.description.abstractThe present study was designed to evaluate the effects of chronic aerobic exercise (swimming, 1h/day, 5 days/week, with an overload of 5% body weight) on glucose metabolism in obese male Wistar rats. Hypothalamic obesity was induced through administration of monosodium glutamate (MSG) at 4 mg/g of body weight every other day from birth to 14 days old. Fourteen weeks after drug administration, the rats were separated into two groups: MSG-S (sedentary) and MSG-T (swimming for 10 weeks). Rats of the same age and strain, receiving saline in place of MSG, were used as control (C), and subdivided into two groups: C-S and C-T. At the end of the experimental period, an oral glucose tolerance test was performed and serum glucose (AG) and insulin (AI) were evaluated. A constant for serum glucose decrease (Kitt) in response to exogenous insulin was calculated. Soleus muscle strips and adipose tissue samples were incubated and insulin stimulated glucose uptake determined. No differences were observed in AG among the 4 groups. MSG-S rats showed higher AI (418%) and lower Kitt (92.3%) than C-S rats. T-rats showed higher glucose uptake by muscle (224.0%) and adipose tissues (94.1%) than S-rats. Among trained rats, glucose uptake by muscle was higher in MSG-T (5.4%) than in C-T. while the opposite was observed in adipose tissue (39% higher in C-T). Chronic aerobic exercise was able to improve glucose tolerance and reduce insulin resistance in MSG-obese rats. These effects were associated to an increase in glucose uptake by muscle and adipose tissue in response to insulin.en
dc.description.affiliationDepto. de Educ. Física, I.B Univ. Estadual Paulista - UNESP, Rio Claro/SP, 13506-900
dc.description.affiliationUnespDepto. de Educ. Física, I.B Univ. Estadual Paulista - UNESP, Rio Claro/SP, 13506-900
dc.format.extent63-71
dc.identifier.citationPhysiological Chemistry and Physics and Medical NMR, v. 33, n. 1, p. 63-71, 2001.
dc.identifier.issn0748-6642
dc.identifier.lattes1173805474635169
dc.identifier.orcid0000-0002-5507-6809
dc.identifier.scopus2-s2.0-0035232534
dc.identifier.urihttp://hdl.handle.net/11449/66741
dc.language.isoeng
dc.relation.ispartofPhysiological Chemistry and Physics and Medical NMR
dc.relation.ispartofsjr0,126
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectfood additive
dc.subjectglucose
dc.subjectglutamate sodium
dc.subjectinsulin
dc.subjectlactic acid
dc.subjectadipose tissue
dc.subjectanimal
dc.subjectanimal experiment
dc.subjectblood
dc.subjectbody composition
dc.subjectfemale
dc.subjectglucose blood level
dc.subjectglucose tolerance test
dc.subjectiatrogenic disease
dc.subjectmale
dc.subjectmetabolism
dc.subjectobesity
dc.subjectphysiology
dc.subjectrat
dc.subjectrat strain
dc.subjectskeletal muscle
dc.subjectweight gain
dc.subjectAdipose Tissue
dc.subjectAnimal
dc.subjectBlood Glucose
dc.subjectBody Composition
dc.subjectFemale
dc.subjectFood Additives
dc.subjectGlucose
dc.subjectGlucose Tolerance Test
dc.subjectInsulin
dc.subjectLactic Acid
dc.subjectMale
dc.subjectMuscle, Skeletal
dc.subjectObesity
dc.subjectPhysical Conditioning, Animal
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSodium Glutamate
dc.subjectSupport, Non-U.S. Gov't
dc.subjectWeight Gain
dc.titleGlucose Tolerance and Insulin Action in Monosodium Glutamate (MSG) Obese Exercise-trained Ratsen
dc.typeArtigo
dcterms.licensehttp://www.physiologicalchemistryandphysics.com/pcp_policy.htm
unesp.advisor.lattes1173805474635169
unesp.advisor.orcid0000-0002-5507-6809
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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