Subacute toxicity assessment of diflubenzuron, an insect growth regulator, in adult male rats

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dc.contributor.authorBarros, Aline Lima de
dc.contributor.authorCavalheiro, Gabriela Finoto
dc.contributor.authorTraesel, Giseli Karenina
dc.contributor.authorSouza, Alexsandra Vila Maior de
dc.contributor.authorGiseli Karenina Trasel
dc.contributor.authorAnselmo-Franci, Janete A
dc.contributor.authorKassuya, Candida Aparecida Leite
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Grande Dourados (UFGD)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-04-01T18:44:48Z
dc.date.available2016-04-01T18:44:48Z
dc.date.issued2014
dc.description.abstractDifubenzuron (DFB), an insecticide and acaricide insect growth regulator, can be used in agriculture against insect predators and in public health programs, to control insects and vectors, mainly Aedes aegypti larvae. Due to the lack of toxicological assessments of this compound, the objective of the present study was to evaluate the toxicological effects of subacute exposure to the DFB insecticide in adult male rats. Adult male rats were exposed (gavage) to 0, 2, 4, or 8 mg/kg of DFB for 28 days. No clinical signs of toxicity were observed in the DFB-treated animals of the experimental groups. However, there was an increase in serum levels of alanine aminotransferase in the group that received 8 mg/Kg/DFB/day and urea at doses of 4 and 8 mg/Kg/DFB/day, without altering other biochemical or hematological parameters. The subacute exposure to the lowest dose of DFB caused significant decrease in testis weight, daily sperm production, and in number of sperm in the epididymis in relation to the control group. However, no alterations were observed in the sperm morphology, testicular, epididymis, liver and kindney histology, or testosterone levels. These findings unveiled the hazardous effects of DFB on male reproduction after the subacute exposure and special attention should be addressed to the effects of low doses of this pesticide.en
dc.description.affiliationSão Paulo State University (UNESP), Department of Morphology, Institute of Biosciences of Botucatu, Botucatu, São Paulo, Brasil
dc.description.affiliationSchool of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil
dc.description.affiliationDepartment of Physiology, Ribeirão Preto Medical School, University of São Paulo (USP).
dc.description.affiliationUnespSão Paulo State University (UNESP), Department of Morphology, Institute of Biosciences of Botucatu, Botucatu, São Paulo, Brasil
dc.description.affiliationUnespSchool of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil
dc.description.affiliationUnespDepartment of Physiology, Ribeirão Preto Medical School, University of São Paulo (USP).
dc.format.extent407-414
dc.identifierhttp://dx.doi.org/10.1002/tox.22054
dc.identifier.citationEnvironmental Toxicology, p. 407-414, 2014.
dc.identifier.doi10.1002/tox.22054
dc.identifier.issn1520-4081
dc.identifier.lattes729220781785349
dc.identifier.urihttp://hdl.handle.net/11449/137235
dc.language.isoeng
dc.relation.ispartofEnvironmental Toxicology
dc.relation.ispartofjcr2.491
dc.relation.ispartofsjr0,652
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectInsecticideen
dc.subjectDiflubenzuronen
dc.subjectSubacute toxicityen
dc.subjectLow-doseen
dc.subjectTestisen
dc.subjectRatsen
dc.titleSubacute toxicity assessment of diflubenzuron, an insect growth regulator, in adult male ratsen
dc.typeArtigo
unesp.author.lattes729220781785349
unesp.author.lattes0729220781785349[8]
unesp.author.orcid0000-0002-2373-9399[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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