Liposomal encapsulation improves the duration of soft tissue anesthesia but does not induce pulpal anesthesia

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dc.contributor.authorFranz-Montan, Michelle
dc.contributor.authorSilva, Andre L. R.
dc.contributor.authorFraceto, Leonardo F. [UNESP]
dc.contributor.authorVolpato, Maria C.
dc.contributor.authorde Paula, Eneida
dc.contributor.authorRanali, Jose
dc.contributor.authorGroppo, Francisco C.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:33:32Z
dc.date.available2014-05-20T15:33:32Z
dc.date.issued2010-08-01
dc.description.abstractStudy Objective: To compare the topical and the pulpal anesthesia efficacy of liposomal and plain benzocaine formulationsDesign: Double-blinded, randomized crossover study.Setting: University ambulatory dental centerPatients: 30 ASA physical status 1 volunteersInterventions: Volunteers received, in three different sessions, topical application of liposome-encapsulated 10% benzocaine (LB10), 10% benzocaine gel (B10), and 20% benzocaine gel (B20) in the right maxillary canine mucobuccal foldMeasurements: Pain associated with the needle insertion was rated by visual analog scale (VAS) and the duration of topical anesthesia was recorded Pulpal anesthesia was evaluated using an electric pulp testerMain Results: VAS values (median. 1st - 3rd quartiles) were 17 cm (11 - 25), 14 cm (3 - 22), and 21 cm (9 21) for B10, LB10, and 1320, respectively No differences were noted among the groups (Friedman test, P = 0 58) Soft tissue anesthesia was also not different The LB10 [10 (8 - 12) min] showed longer soft tissue anesthesia (Friedman test, P < 0 01) than the other agents [1310 = 8 (5 - 10) min, and B20 = 7 (6 - 9) min] None of the topical benzocaine formulations tested induced pulpal anesthesiaConclusions: The encapsulation of benzocaine into liposome increased the duration of soft tissue anesthesia However, it did not induce pulpal anesthesia (C) 2010 Elsevier Inc All rights reserveden
dc.description.affiliationState Univ Campinas UNICAMP, Dept Physiol Sci, Piracicaba Dent Sch, BR-13414903 São Paulo, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Dept Biochem, Inst Biol, BR-13083862 São Paulo, Brazil
dc.description.affiliationJulio Mesquita Filho State Univ, Dept Environm Engn, BR-18087180 São Paulo, Brazil
dc.description.affiliationUnespJulio Mesquita Filho State Univ, Dept Environm Engn, BR-18087180 São Paulo, Brazil
dc.description.sponsorshipDFL Ind Corn Ltda, Rio de Janeiro, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent313-317
dc.identifierhttp://dx.doi.org/10.1016/j.jclinane.2010.03.001
dc.identifier.citationJournal of Clinical Anesthesia. New York: Elsevier B.V., v. 22, n. 5, p. 313-317, 2010.
dc.identifier.doi10.1016/j.jclinane.2010.03.001
dc.identifier.issn0952-8180
dc.identifier.urihttp://hdl.handle.net/11449/42135
dc.identifier.wosWOS:000280532800002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Clinical Anesthesia
dc.relation.ispartofjcr1.818
dc.relation.ispartofsjr0,484
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBenzocaineen
dc.subjectDentistryen
dc.subjectDrug encapsulationen
dc.subjectInjection painen
dc.subjectLiposomeen
dc.subjectLocal anestheticen
dc.subjectTopical anesthesiaen
dc.titleLiposomal encapsulation improves the duration of soft tissue anesthesia but does not induce pulpal anesthesiaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Sorocabapt

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