Single early prenatal lipopolysaccharide exposure impairs striatal monoamines and maternal care in female rats

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dc.contributor.authorSoto, Ana M. S. [UNESP]
dc.contributor.authorKirsten, Thiago B.
dc.contributor.authorReis-Silva, Thiago M.
dc.contributor.authorMartins, Maria F. M. [UNESP]
dc.contributor.authorTeodorov, Elisabeth
dc.contributor.authorFlorio, Jorge C.
dc.contributor.authorPalermo-Neto, Joao
dc.contributor.authorBernardi, Maria M. [UNESP]
dc.contributor.authorBondan, Eduardo F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2014-12-03T13:08:43Z
dc.date.available2014-12-03T13:08:43Z
dc.date.issued2013-05-02
dc.description.abstractAims: Environmental information received by a mother can induce a phenotype change in her offspring, commonly known as a maternal effect (trans-generational effect). The present work verified the effects of lipopolysaccharide (LPS), which mimics bacterial infection, on maternal care and on the activity of related brain areas in F1 offspring, i.e., female rats that were prenatally exposed to LPS.Main methods: Pregnant rats received 100 mu g/kg of LPS intraperitoneally on gestational day (GD) 9.5. Female offspring of the F1 generation were mated to naive males and were evaluated during their lactation period for open field, maternal and aggressive behaviors. Striatal and hypothalamic dopamine and serotonin levels and turnover were also evaluated. Furthermore, astrocyte protein expression in the nucleus accumbens (NA) was analyzed in F1 females to assess LPS-induced neuroinflammation.Key findings: Prenatal LPS did not change open field behavior but impaired both maternal and maternal aggressive behaviors in the F1 generation. LPS exposure also reduced both striatal levels of dopamine and serotonin and its metabolites, but induced no changes in NA astrocyte expression.Significance: We suggested that the observed impairments in the F1 females were a consequence of a motivational change induced by prenatal LPS, as (1) no changes in motor activity were observed, (2) prenatal LPS-exposure was reported by our group to induce motivational impairments in males, and (3) the existence of a strong connection between striatal dopaminergic activity and motivation-oriented activities. The present findings strongly indicate a maternal effect for prenatal LPS, at least for the F1 generation. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Hlth Sci Inst, BR-04026002 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Pathol, Sch Vet Med, BR-05508270 Sao Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Matemat Comp & Cognicao, BR-09210971 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Hlth Sci Inst, BR-04026002 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent852-858
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2013.03.003
dc.identifier.citationLife Sciences. Oxford: Pergamon-elsevier Science Ltd, v. 92, n. 14-16, p. 852-858, 2013.
dc.identifier.doi10.1016/j.lfs.2013.03.003
dc.identifier.fileWOS000318190900006.pdf
dc.identifier.issn0024-3205
dc.identifier.urihttp://hdl.handle.net/11449/111508
dc.identifier.wosWOS:000318190900006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLife Sciences
dc.relation.ispartofjcr3.234
dc.relation.ispartofsjr1,071
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectDopamineen
dc.subjectMaternal aggressive behavioren
dc.subjectMaternal immune activationen
dc.subjectNeuroinflammationen
dc.subjectNucleus accumbensen
dc.subjectSerotoninen
dc.subjectTrans-generational effectsen
dc.titleSingle early prenatal lipopolysaccharide exposure impairs striatal monoamines and maternal care in female ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-3887-0023[9]
unesp.author.orcid0000-0002-4134-4307[3]
unesp.author.orcid0000-0002-4032-4355[2]
unesp.author.orcid0000-0002-6860-9416[8]

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