5CN05 partitioning in an aqueous two-phase system: A new approach to the solubilization of hydrophobic drugs

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dc.contributor.authorLopes, Andre Moreni
dc.contributor.authorSantos-Ebinuma, Valeria de Carvalho [UNESP]
dc.contributor.authorApolinario, Alexsandra Conceicao
dc.contributor.authorBezerra Mendonca, Francisco Jaime
dc.contributor.authorGoulart de Lima Damasceno, Bolivar Ponciano
dc.contributor.authorPessoa, Adalberto
dc.contributor.authorSilva, Jose Alexsandro da
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionState Univ Paraiba
dc.date.accessioned2015-03-18T15:53:59Z
dc.date.available2015-03-18T15:53:59Z
dc.date.issued2014-09-01
dc.description.abstractLiquid-liquid extraction for the purification of molecules has been central to many advances in the pharmaceutical industry. These processes were developed based on the property that some polymer and/or micellar solutions present to separate into a concentrated phase and a diluted phase. Based on the differences in the physical and chemical environments of the two coexisting phases, and since both phases contain approximately 60-90% of water, liquid-liquid extraction provides a powerful alternative to both extract and solubilize a molecule. This paper examines the partition behavior of the synthetic drug, 2-[(3,4-dichlorine-benzylidene)-amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (5CN05), in an aqueous two-phase polymer system (ATPPS) and also in an aqueous two-phase micellar system (ATPMS). The results showed that both systems are favorable for extraction the 5CN05 drug high partition coefficient values (K-5CN05 > 200) and yield (Y-5CN05 > 99.48%) in the concentrated phase were achieved with the systems. However, the ATPPS generated a partition coefficient (K-5CN05) higher than the one obtained with ATPMS. The results suggest that both processes may be used for the extraction and concentration of molecules with hydrophobic characteristics, such as 5CN05. They also provide an optimal environment for the solubilization of such molecules, allowing for greater efficiency when purifying many classes of drugs. (C) 2014 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Sch Pharmaceut Sci, Dept Biochem & Pharmaceut Technol, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Sch Pharmaceut Sci, Dept Bioproc & Biotechnol, Sao Paulo, Brazil
dc.description.affiliationState Univ Paraiba, Grad Program Pharmaceut Sci, Campina Grande, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Sch Pharmaceut Sci, Dept Bioproc & Biotechnol, Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 552652/2011-3
dc.description.sponsorshipIdFAPESP: 13/22212-0
dc.format.extent1555-1561
dc.identifierhttp://dx.doi.org/10.1016/j.procbio.2014.05.017
dc.identifier.citationProcess Biochemistry. Oxford: Elsevier Sci Ltd, v. 49, n. 9, p. 1555-1561, 2014.
dc.identifier.doi10.1016/j.procbio.2014.05.017
dc.identifier.issn1359-5113
dc.identifier.urihttp://hdl.handle.net/11449/116717
dc.identifier.wosWOS:000341549600024
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProcess Biochemistry
dc.relation.ispartofjcr2.616
dc.relation.ispartofsjr0,761
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPEGen
dc.subjectTriton X-114en
dc.subject5CN05en
dc.subjectLiquid-liquid extractionen
dc.subjectAqueous two-phase systemsen
dc.title5CN05 partitioning in an aqueous two-phase system: A new approach to the solubilization of hydrophobic drugsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-6666-6695[2]
unesp.author.orcid0000-0002-5268-8690[6]
unesp.author.orcid0000-0002-3570-2470[1]
unesp.author.orcid0000-0002-8840-8486[4]
unesp.author.orcid0000-0001-5015-7530[3]
unesp.author.orcid0000-0003-3588-833X[4]

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