The influence of ACE genotype on cardiorespiratory fitness of moderately active young men

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dc.contributor.authorAlmeida, Jeeser Alves
dc.contributor.authorBoullosa, Daniel Alexandre
dc.contributor.authorPardono, Emerson
dc.contributor.authorLima, Ricardo Moreno
dc.contributor.authorMorais, Pâmella Karoline
dc.contributor.authorDenadai, Benedito Sérgio [UNESP]
dc.contributor.authorSouza, Vinícius Carolino
dc.contributor.authorNóbrega, Otávio Toledo
dc.contributor.authorCampbell, Carmen Sílvia Grubert
dc.contributor.authorSimões, Herbert Gustavo
dc.contributor.institutionPPGEF - UCB - QS 07
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:48:56Z
dc.date.available2022-04-29T08:48:56Z
dc.date.issued2012-04-01
dc.description.abstractBackground: The angiotensin I-converting enzyme gene (ACE gene) has been broadly studied as for cardiorespiratory fitness phenotypes, but the association of the ACE genotype to middle-distance running has been poorly investigated. Objective: This study investigated the possible influence of Angiotensin-Converting Enzyme (ACE) genotype (I/D) on cardiovascular fitness and middle-distance running performance of Brazilian young males. The validity of VO2max prediction with regard to the ACE genotype was also analyzed. Methods: A homogeneous group of moderately active young males were evaluated in a 1,600 m running track test (V1600m; m.min-1) and in an incremental treadmill test for VO2max determination. Subsequently, the actual and the predicted [(0.177*V1600m) + 8.101] VO2max were compared to ACE genotypes. Results: The VO2max and V1600m recorded for DD, ID and II genotypes were 45.6 (1.8); 51.9 (0.8) and 54.4 (1.0) mL.kg-1. min-1 and 211.2 (8.3); 249.1 (4.3) and 258.6 (5.4) m.min-1 respectively, and were significantly lower for DD carriers (p< 0.05). The actual and predicted VO2max did not differ from each other despite ACE genotype, but the agreement between actual and estimated VO2max methods was lower for the DD genotype. Conclusion: It was concluded that there is a possible association between ACE genotype, cardiovascular fitness and middle-distance running performance of moderately active young males and that the accuracy of VO2max prediction may also depend on the ACE genotype of the participants.en
dc.description.affiliationUniversidade Católica de Brasília PPGEF - UCB - QS 07, LT1 S/N - Bloco, G - Sala 119, 72030-170 - Águas Claras, DF
dc.description.affiliationUniversidade de Brasília, Brasília, DF
dc.description.affiliationUniversidade Federal de Sergipe, Aracaju, SE
dc.description.affiliationUniversidade Estadual Paulista UNESP, São Paulo, SP
dc.description.affiliationUnespUniversidade Estadual Paulista UNESP, São Paulo, SP
dc.format.extent315-320
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2012005000029
dc.identifier.citationArquivos Brasileiros de Cardiologia, v. 98, n. 4, p. 315-320, 2012.
dc.identifier.doi10.1590/S0066-782X2012005000029
dc.identifier.issn0066-782X
dc.identifier.issn1678-4170
dc.identifier.scopus2-s2.0-84863896494
dc.identifier.urihttp://hdl.handle.net/11449/232085
dc.language.isoeng
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.sourceScopus
dc.subjectAngiotensin-converting enzyme
dc.subjectI/D polymorphism
dc.subjectMiddle-distance running
dc.subjectVO2max
dc.titleThe influence of ACE genotype on cardiorespiratory fitness of moderately active young menen
dc.typeArtigo

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