Cisplatin chemotherapy impairs the peri-implant bone repair around titanium implants: An in vivo study in rats

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dc.contributor.authorMatheus, Henrique Rinaldi [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorFaleiros, Paula Lazilha [UNESP]
dc.contributor.authorNovaes, Vivian Cristina Noronha [UNESP]
dc.contributor.authorTheodoro, Leticia Helena [UNESP]
dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorde Almeida, Juliano Milanezi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:35:06Z
dc.date.available2018-12-11T17:35:06Z
dc.date.issued2018-02-01
dc.description.abstractAim: The purpose of this study in animals was to evaluate the peri-implant bone repair against systemic administration of the antineoplastic agent. Material and methods: We used 84 male rats (Rattus norvegicus, albinus, Wistar), divided into two groups: cisplatin (CIS) and saline solution (SS). The titanium implants were inserted into the right tibia at day 0 in all animals from both groups. Group SS received SS intraperitoneally at 15 and 17 days postoperatively. Group CIS received 5 and 2.5 mg/kg of CIS intraperitoneally at 15 and 17 days postoperatively, respectively. Euthanasia was performed at 22, 30 and 60 days postoperatively. Twenty-four undecalcified specimens were prepared for histometric analysis of bone/implant contact (BIC). Sixty specimens were selected to bone area (BA) measurement, histological analysis and immunohistochemical analysis of RUNX-2, osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP). BIC and BA were considered to be the primary outcome parameters. Results: Group CIS showed lower BIC (11.87 ± 0.97 mm; 19.19 ± 0.8 mm; 17.69 ± 1.05 mm; p ≤.05) and BA (3.68 ± 1.29 mm2; 3.05 ± 0.88 mm2; 3.23 ± 0.67 mm2; p ≤.05), as well as decreased number of RUNX-2 (102.8 ± 27.35 cells/mm2; 100.04 ± 8.61 cells/mm2; 118.82 ± 21.38 cells/mm2; p ≤.05)- and OCN-positive cells (120 ± 24.5 cells/mm2; 102 ± 27.73 cells/mm2; 100 ± 14.23 cells/mm2; p ≤.05) at 22, 30 and 60 days, respectively. The animals in group CIS also showed increased number of TRAP-positive cells (86.8 ± 6.37 cells/mm2; 71.5 ± 4.72 cells/mm2; 92.8 ± 9.52 cells/mm2; p ≤.05) and a persistent and exacerbated inflammatory response in all experimental periods. Conclusion: Within the limits of this study, it was concluded that the chemotherapeutic CIS negatively affects the bone repair at peri-implant areas, jeopardizing the osseointegration of titanium implants.en
dc.description.affiliationDepartment of Surgery and Integrated Clinic—Periodontics Division School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Basic Science School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Surgery and Integrated Clinic—Periodontics Division School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Basic Science School of Dentistry São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: #2015/20994-6
dc.format.extent241-252
dc.identifierhttp://dx.doi.org/10.1111/jcpe.12824
dc.identifier.citationJournal of Clinical Periodontology, v. 45, n. 2, p. 241-252, 2018.
dc.identifier.doi10.1111/jcpe.12824
dc.identifier.issn1600-051X
dc.identifier.issn0303-6979
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-85037332092
dc.identifier.urihttp://hdl.handle.net/11449/179416
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Periodontology
dc.relation.ispartofsjr2,079
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectantineoplastic agents
dc.subjectbone repair
dc.subjectchemotherapy
dc.subjectdental implants
dc.subjectosseointegration
dc.titleCisplatin chemotherapy impairs the peri-implant bone repair around titanium implants: An in vivo study in ratsen
dc.typeArtigo
unesp.author.lattes4408095517346846[2]
unesp.author.orcid0000-0002-5995-5747[7]
unesp.author.orcid0000-0003-4859-0583[2]

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Artigos - Ciências Básicas - FOA
Artigos - Cirurgia e Clínica Integrada - FOA