Effects of isoflurane on echocardiographic parameters in healthy dogs

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dc.contributor.authorSousa, Marlos G. [UNESP]
dc.contributor.authorCarareto, Roberta [UNESP]
dc.contributor.authorDe-Nardi, Andrigo B. [UNESP]
dc.contributor.authorBrito, Fabio L. C. [UNESP]
dc.contributor.authorNunes, Newton
dc.contributor.authorCamacho, Aparecido Antonio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:14:16Z
dc.date.available2014-05-20T13:14:16Z
dc.date.issued2008-05-01
dc.description.abstractObejective To study the echocardiographic effects of isoflurane at an end-tidal concentration approximating 1.0 times the minimum alveolar concentration (MAC) in healthy unpremedicated dogs.Study design Prospective experimental trial.Animals Sixteen mature mongrel dogs of either sex weighing 11.06 +/- 2.72 kg.Methods After performing a baseline echocardiogram in the awake animal, anesthesia was induced with increasing inspired concentrations of isoflurane via a face mask until tracheal intubation was possible. Following intubation, the end-tidal concentration was decreased to 1.4% for the rest of the anesthetic period. Serial echocardiograms were recorded at 25, 40, and 55 minutes after the end-tidal concentration was reached.Results No changes were observed in heart rate. However, significant decreases were seen in left ventricular end-diastolic diameter (Mean maximal change: 13.8%), interventricular septal thickness during systole (15.2%), interventricular septal thickening fraction (72.2%), left ventricular free wall thickening fraction (63.5%), ejection fraction (39.9%), and fractional shortening (46.7%). In addition, peak flow velocities across mitral, pulmonic, and aortic valves were significantly lower than baseline values. Decreases were also observed in end-diastolic left ventricular volume index (approximately 32.1% from the awake value), stroke index (58.2%), and cardiac index (55.3%) when compared with awake measurements.Conclusions Our results indicate that 1 x MAC isoflurane caused significant myocardial depression in healthy dogs. These changes in myocardial function need to be considered carefully when isoflurane is to be used in dogs with poor cardiovascular reserve.en
dc.description.affiliationUniv Estadual Paulista, Dept Clin & Cirurg Vet, Fac Ciencias Agrarias & Vet, Coll Agr & Vet Sci, BR-14884900 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Clin & Cirurg Vet, Fac Ciencias Agrarias & Vet, Coll Agr & Vet Sci, BR-14884900 São Paulo, Brazil
dc.format.extent185-190
dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.2007.00370.x
dc.identifier.citationVeterinary Anaesthesia and Analgesia. Oxford: Blackwell Publishing, v. 35, n. 3, p. 185-190, 2008.
dc.identifier.doi10.1111/j.1467-2995.2007.00370.x
dc.identifier.issn1467-2987
dc.identifier.lattes0023783814889740
dc.identifier.lattes9642688764978907
dc.identifier.urihttp://hdl.handle.net/11449/1795
dc.identifier.wosWOS:000254793700002
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofVeterinary Anaesthesia and Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectechocardiographyen
dc.subjectHemodynamicsen
dc.subjectleft ventricular functionen
dc.subjectvolatile anestheticsen
dc.titleEffects of isoflurane on echocardiographic parameters in healthy dogsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
unesp.author.lattes0023783814889740
unesp.author.lattes9642688764978907[6]
unesp.author.lattes5256503293611165[3]
unesp.author.orcid0000-0003-1367-9828[1]
unesp.author.orcid0000-0001-6463-2144[3]
unesp.author.orcid0000-0001-9802-9271[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Clínica e Cirurgia Veterinária - FCAV