A comparative study on asymmetric reduction of ketones using the growing and resting cells of marine-derived fungi

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dc.contributor.authorLiu, Hui
dc.contributor.authorChen, Bi-Shuang
dc.contributor.authorRibeiro de Souza, Fayene Zeferino [UNESP]
dc.contributor.authorLiu, Lan
dc.contributor.institutionSun Yat-Sen University
dc.contributor.institutionGuangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:52:00Z
dc.date.available2018-12-11T16:52:00Z
dc.date.issued2018-02-01
dc.description.abstractWhole-cell biocatalysts offer a highly enantioselective, minimally polluting route to optically active alcohols. Currently, most of the whole-cell catalytic performance involves resting cells rather than growing cell biotransformation, which is one-step process that benefits from the simultaneous growth and biotransformation, eliminating the need for catalysts preparation. In this paper, asymmetric reduction of 14 aromatic ketones to the corresponding enantiomerically pure alcohols was successfully conducted using the growing and resting cells of marine-derived fungi under optimized conditions. Good yields and excellent enantioselectivities were achieved with both methods. Although substrate inhibition might be a limiting factor for growing cell biotransformation, the selected strain can still completely convert 10-mM substrates into the desired products. The resting cell biotransformation showed a capacity to be recycled nine times without a significant decrease in the activity. This is the first study to perform asymmetric reduction of ketones by one-step growing cell biotransformation.en
dc.description.affiliationSchool of Marine Sciences Sun Yat-Sen University
dc.description.affiliationGuangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering
dc.description.affiliationSouth China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center Sun Yat-Sen University
dc.description.affiliationDepartamento de Química Faculdade de Ciências UNESP
dc.description.affiliationUnespDepartamento de Química Faculdade de Ciências UNESP
dc.description.sponsorshipSun Yat-sen University
dc.description.sponsorshipCommonwealth Fund
dc.description.sponsorshipNatural Science Foundation of Guangdong Province
dc.description.sponsorshipNational Natural Science Foundation of China
dc.description.sponsorshipConsiliul National pentru Dezvoltare si Inovare
dc.description.sponsorshipIdSun Yat-sen University: 17lgpy58
dc.description.sponsorshipIdCommonwealth Fund: 201305017
dc.description.sponsorshipIdNatural Science Foundation of Guangdong Province: 2017A030310232
dc.description.sponsorshipIdNational Natural Science Foundation of China: 41706148
dc.description.sponsorshipIdConsiliul National pentru Dezvoltare si Inovare: GD2012-D01-001
dc.identifierhttp://dx.doi.org/10.3390/md16020062
dc.identifier.citationMarine Drugs, v. 16, n. 2, 2018.
dc.identifier.doi10.3390/md16020062
dc.identifier.file2-s2.0-85042374617.pdf
dc.identifier.issn1660-3397
dc.identifier.scopus2-s2.0-85042374617
dc.identifier.urihttp://hdl.handle.net/11449/170689
dc.language.isoeng
dc.relation.ispartofMarine Drugs
dc.relation.ispartofsjr0,978
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAsymmetric reduction
dc.subjectChiral alcohols
dc.subjectGrowing cells
dc.subjectMarine fungi
dc.subjectResting cells
dc.titleA comparative study on asymmetric reduction of ketones using the growing and resting cells of marine-derived fungien
dc.typeArtigo

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