Dysautonomia and ventricular dysfunction in the indeterminate form of Chagas disease

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dc.contributor.authorMolina, Roberta B. G.
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorHueb, João Carlos [UNESP]
dc.contributor.authorZanati, Silmeia Garcia
dc.contributor.authorMeira, Domingos A.
dc.contributor.authorCassolato, Jose Luiz
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCardios & Hosp 9 de Julho
dc.date.accessioned2014-05-20T13:32:53Z
dc.date.available2014-05-20T13:32:53Z
dc.date.issued2006-11-10
dc.description.abstractBackground: the associations between autonomic function and biventricular function in patients with the indeterminate form of Chagas disease remains to be elucidated.Methods: In 42 asymptornatic patients and 19 healthy volunteers, the autonomic function was assessed by time domain indices of heart rate variability (HRV), analyzed for 24 h; the right ventricular function was assessed by fraction area change, right ventricle shortening, and systolic excursion of the tricuspid valve; and the left ventricular function was assessed by ejection fraction and transmittal flow velocities. Data were expressed as mean SD or medians (including the lower quartile and upper quartile). Groups were compared by Student's t or Mann-Whitney U test. Autonomic and ventricular function were correlated by Pearson's or Spearman's correlation coefficient. The level of significance was 5%.Results: Right and left ventricular systolic function indexes were comparable between groups. Transmittal flow velocities were decreased in the Chagas disease group (p < 0.05). The patients presented impaired HRV as indicated by the values of SDNN-day (80 (64-99) ms vs. 98 (78-127) ms; p = 0.045), SDNNI-24 It (54 (43-71) vs. 65 (54-105) ms; p = 0.027), SDNNI-day (49 (42-64) vs. 67 (48-76) ms; p = 0.045), pNN50-day (2.2 (0.7-5)% vs. 10 (3-11)%; p = 0.033); and pNN50-24 It (3 (1-7)% vs. 12 (8-19)%; p = 0.013). There were no correlations between the left ventricular diastolic indices and autonomic dysfunctional indices (p > 0.05).Conclusion: Patients with the indeterminate form of Chagas disease have both dysautonomia, and left ventricular diastolic dysfunction. However, the right ventricular function is preserved. Importantly, ventricular diastolic dysfunction and dysautonomia. are independent phenomena. (c) 2005 Elsevier B.V.. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Clin Med, Fac Med Botucatu, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Molestias Infecciosas, Fac Med Botucatu, São Paulo, Brazil
dc.description.affiliationCardios & Hosp 9 de Julho, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Clin Med, Fac Med Botucatu, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Molestias Infecciosas, Fac Med Botucatu, São Paulo, Brazil
dc.format.extent188-193
dc.identifierhttp://dx.doi.org/10.1016/j.ijcard.2005.11.010
dc.identifier.citationInternational Journal of Cardiology. Clare: Elsevier B.V., v. 113, n. 2, p. 188-193, 2006.
dc.identifier.doi10.1016/j.ijcard.2005.11.010
dc.identifier.issn0167-5273
dc.identifier.lattes6990977122340795
dc.identifier.lattes5016839015394547
dc.identifier.urihttp://hdl.handle.net/11449/11240
dc.identifier.wosWOS:000242312500007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Cardiology
dc.relation.ispartofjcr4.034
dc.relation.ispartofsjr1,200
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdiastolic dysfunctionpt
dc.subjectright ventricular functionpt
dc.subjectautonomic controlpt
dc.titleDysautonomia and ventricular dysfunction in the indeterminate form of Chagas diseaseen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5016839015394547
unesp.author.lattes6990977122340795
unesp.author.orcid0000-0002-0607-8189[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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