Genotoxicity and cytotoxicity of mineral trioxide aggregate and regular and white Portland cements on Chinese hamster ovary (CHO) cells in vitro

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dc.contributor.authorRibeiro, D. A.
dc.contributor.authorSugui, M. M.
dc.contributor.authorMatsumoto, M. A.
dc.contributor.authorDuarte, MAH
dc.contributor.authorMarques, MEA
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Bauru
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:20:23Z
dc.date.available2014-05-20T15:20:23Z
dc.date.issued2006-02-01
dc.description.abstractObjective. Recently, mineral trioxide aggregate (MTA) and Portland cement have been used in dentistry as root-end-filling materials. However, the reported results concerning the biocompatibility of these materials are inconsistent. The goal of this study was to examine the genotoxicity and cytotoxicity of MTA and Portland cements in vitro by the single-cell gel (comet) assay and trypan blue exclusion test.Study design. Chinese hamster ovary (CHO) cells were exposed to MTA and regular and white Portland cements at final concentration ranging from 1 to 1000 mu g/mL for 1 h at 37 degrees C.Results. All compounds tested did not show genotoxic effects in all concentrations evaluated. No significant differences (P > .05) in cytotoxicity were observed for all compounds tested.Conclusions. Taken together, our results suggest that MTA and Portland cements are not genotoxins and are not able to induce cellular death.en
dc.description.affiliationBotucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationUniv Bauru, Dept Endodontol, Bauru, Brazil
dc.format.extent260-263
dc.identifierhttp://dx.doi.org/10.1016/j.tripleo.2005.02.080
dc.identifier.citationOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics. St Louis: Mosby, Inc., v. 101, n. 2, p. 260-263, 2006.
dc.identifier.doi10.1016/j.tripleo.2005.02.080
dc.identifier.issn1079-2104
dc.identifier.lattes5051118752980903
dc.identifier.orcid0000-0001-5389-0105
dc.identifier.urihttp://hdl.handle.net/11449/31706
dc.identifier.wosWOS:000235299200020
dc.language.isoeng
dc.publisherMosby, Inc
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleGenotoxicity and cytotoxicity of mineral trioxide aggregate and regular and white Portland cements on Chinese hamster ovary (CHO) cells in vitroen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderMosby, Inc
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[6]
unesp.author.orcid0000-0001-5389-0105[3]
unesp.author.orcid0000-0003-3051-737X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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