Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model

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dc.contributor.authorMorais Lima, Gedson Rodrigues de
dc.contributor.authorFrota Machado, Flavia Danniele
dc.contributor.authorLucena Perico, Larissa [UNESP]
dc.contributor.authorMeira de Faria, Felipe
dc.contributor.authorLuiz-Ferreira, Anderson
dc.contributor.authorSouza Brito, Alba Regina Monteiro
dc.contributor.authorHelena Pellizzon, Cludia [UNESP]
dc.contributor.authorAkiko Hiruma-Lima, Claudia [UNESP]
dc.contributor.authorFechine Tavares, Josean
dc.contributor.authorBarbosa Filho, Jose Maria
dc.contributor.authorMaria Batista, Leonia
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2018-11-26T15:43:42Z
dc.date.available2018-11-26T15:43:42Z
dc.date.issued2017-02-28
dc.description.abstractAIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of Combretum duarteanum (Cd). METHODS Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS Both Cd-EtOHE and Cd-HexP caused significant reductions in macroscopic lesion scores and ulcerative lesion areas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-alpha and IL-1 beta. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase. CONCLUSION The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.en
dc.description.affiliationUniv Fed Paraiba UFPB, Lab Farmacol Trato Gastrintestinal, Ctr Ciencias Saude, Dept Ciencias Farmaceut, Cidade Univ,S-N Castelo Branco, BR-58051970 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas UNICAMP, Inst Biol, Dept Biol Estrutural & Func, BR-13083970 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Goias, Inst Biotecnol, Dept Ciencias Biol, BR-75704020 Catalao, Go, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Morfol, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Morfol, BR-18618970 Sao Paulo, Brazil
dc.format.extent1353-1366
dc.identifierhttp://dx.doi.org/10.3748/wjg.v23.i8.1353
dc.identifier.citationWorld Journal Of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 23, n. 8, p. 1353-1366, 2017.
dc.identifier.doi10.3748/wjg.v23.i8.1353
dc.identifier.fileWOS000395823500005.pdf
dc.identifier.issn1007-9327
dc.identifier.urihttp://hdl.handle.net/11449/159419
dc.identifier.wosWOS:000395823500005
dc.language.isoeng
dc.publisherBaishideng Publishing Group Inc
dc.relation.ispartofWorld Journal Of Gastroenterology
dc.relation.ispartofsjr1,409
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCombretum duarteanum
dc.subjectMedicinal plants
dc.subjectCombretaceae
dc.subjectInflammatory bowel disease
dc.subjectAnti-inflammatory intestinal activity
dc.titleAnti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis modelen
dc.typeArtigo
dcterms.rightsHolderBaishideng Publishing Group Inc
unesp.author.orcid0000-0002-0888-9911[3]
unesp.author.orcid0000-0002-9567-4096[10]

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