Accuracy of four ultrasonography techniques in predicting histopathological classification of canine mammary carcinomas

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dc.contributor.authorFeliciano, Marcus Antonio Rossi [UNESP]
dc.contributor.authorRamirez, Ricardo Andrés Uscategui [UNESP]
dc.contributor.authorMaronezi, Marjury Cristina [UNESP]
dc.contributor.authorMaciel, Giovanna Serpa [UNESP]
dc.contributor.authorAvante, Michelle Lopes [UNESP]
dc.contributor.authorSenhorello, Igor Luiz Salardani [UNESP]
dc.contributor.authorMucédola, Talita [UNESP]
dc.contributor.authorGasser, Beatriz [UNESP]
dc.contributor.authorCarvalho, Cibele Figueira
dc.contributor.authorVicente, Wilter Ricardo Russiano [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUFRB—Universidade Federal do Recôncavo da Bahia
dc.contributor.institutionNAUS—Núcleo de Aperfeiçoamento em Ultrassonografia Veterinária
dc.date.accessioned2018-12-11T17:35:42Z
dc.date.available2018-12-11T17:35:42Z
dc.date.issued2018-07-01
dc.description.abstractDue to the importance of presurgical, noninvasive, and accurate diagnostic tools in mammary carcinoma characterization, this prospective secondary observational cohort study was designed to evaluate and compare the diagnostic accuracy of B-mode, Doppler, contrast enhancement ultrasonography, or acoustic radiation force impulse–elastography in identifying mammary carcinomas types with high degree of malignancy. A total of 246 mammary carcinomas from 141 female dogs were analyzed using B-mode, Doppler, contrast enhancement ultrasonography, and acoustic radiation force impulse ultrasonography prior to their histopathological classification according to types (simple, complex, or special) and grade (I, II, or III). Qualitative and quantitative variables were compared between carcinoma types and grades by Fisher's or analysis of variance. Diagnostic performance was estimated by receiver-operating characteristic analysis, using histopathological classification as a reference. Deformability (acoustic radiation force impulse) had a diagnostic specificity of 100% and sensitivity of 12% in identifying special carcinomas. A width:length ratio greater than 0.53 can be suggestive of special carcinoma, with 80% sensitivity and 76% specificity. Contrast wash-in and peak enhancement times lower than 7.5 and 13.5 s, respectively, were indicative of complex carcinoma at 62% sensitivity and 60% specificity. Contrast wash-in, peak enhancement, and wash-out times greater than 6.5, 12.5, and 64.5 s, respectively; were indicative of grade II and III carcinoma at 68% sensitivity and 62% specificity. In conclusion, B-mode ultrasonography, contrast enhancement ultrasonography, and acoustic radiation force impulse–elastography enabled the identification of some of the characteristics of high-grade mammary carcinoma types and grades in female dogs with limited accuracy. The findings from this study may contribute to oncology research and clinical management canine patients.en
dc.description.affiliationUNESP—Universidade Estadual Paulista Julio de Mesquita Filho Faculdade de Ciencias Agrarias e Veterinarias Campus Jaboticabal
dc.description.affiliationUFRB—Universidade Federal do Recôncavo da Bahia
dc.description.affiliationNAUS—Núcleo de Aperfeiçoamento em Ultrassonografia Veterinária
dc.description.affiliationUnespUNESP—Universidade Estadual Paulista Julio de Mesquita Filho Faculdade de Ciencias Agrarias e Veterinarias Campus Jaboticabal
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/16635-2
dc.description.sponsorshipIdFAPESP: 2013/06443-1
dc.description.sponsorshipIdFAPESP: 2013/23901-3
dc.format.extent444-452
dc.identifierhttp://dx.doi.org/10.1111/vru.12606
dc.identifier.citationVeterinary Radiology and Ultrasound, v. 59, n. 4, p. 444-452, 2018.
dc.identifier.doi10.1111/vru.12606
dc.identifier.issn1740-8261
dc.identifier.issn1058-8183
dc.identifier.scopus2-s2.0-85041713092
dc.identifier.urihttp://hdl.handle.net/11449/179571
dc.language.isoeng
dc.relation.ispartofVeterinary Radiology and Ultrasound
dc.relation.ispartofsjr0,774
dc.relation.ispartofsjr0,774
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectcanine
dc.subjectcontrast-enhanced ultrasound
dc.subjectDoppler
dc.subjectelastography
dc.subjecttumors
dc.titleAccuracy of four ultrasonography techniques in predicting histopathological classification of canine mammary carcinomasen
dc.typeArtigo

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