Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus

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dc.contributor.authorCoronado, Monika A. [UNESP]
dc.contributor.authorGabdulkhakov, Azat
dc.contributor.authorGeorgieva, Dessislava
dc.contributor.authorSankaran, Banumathi
dc.contributor.authorMurakami, Mario T.
dc.contributor.authorArni, Raghuvir K. [UNESP]
dc.contributor.authorBetzel, Christian
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Hamburg
dc.contributor.institutionRAS
dc.contributor.institutionLawrence Berkeley Natl Lab
dc.contributor.institutionNatl Ctr Energy & Mat Res
dc.date.accessioned2014-12-03T13:11:09Z
dc.date.available2014-12-03T13:11:09Z
dc.date.issued2013-10-01
dc.description.abstractThe crystal structure of the myotoxic, cell-penetrating, basic polypeptide crotamine isolated from the venom of Crotalus durissus terrificus has been determined by single-wavelength anomalous dispersion techniques and refined at 1.7 angstrom resolution. The structure reveals distinct cationic and hydrophobic surface regions that are located on opposite sides of the molecule. This surface-charge distribution indicates its possible mode of interaction with negatively charged phospholipids and other molecular targets to account for its diverse pharmacological activities. Although the sequence identity between crotamine and human beta-defensins is low, the three-dimensional structures of these functionally related peptides are similar. Since crotamine is a leading member of a large family of myotoxic peptides, its structure will provide a basis for the design of novel cell-penetrating molecules.en
dc.description.affiliationSao Paulo State Univ, UNESP IBILCE, Dept Phys, Multi User Ctr Biomol Innovat, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Hamburg, Inst Biochem & Mol Biol, D-20146 Hamburg, Germany
dc.description.affiliationRAS, Inst Prot Res, Pushchino 142290, Moscow Region, Russia
dc.description.affiliationLawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94702 USA
dc.description.affiliationNatl Ctr Energy & Mat Res, Biosci Natl Lab, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP IBILCE, Dept Phys, Multi User Ctr Biomol Innovat, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipDeutsche Forschungsgemeinschaft
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipDAAD
dc.description.sponsorshipAlexander von Humboldt Foundation (AvH), Bonn, Germany
dc.description.sponsorshipNational Institutes of Health, National Institute of General Medical Sciences
dc.description.sponsorshipHoward Hughes Medical Institute
dc.description.sponsorshipUS Department of Energy
dc.description.sponsorshipIdDeutsche ForschungsgemeinschaftBE 1443-18-1
dc.description.sponsorshipIdDeutsche Forschungsgemeinschaft26-1
dc.description.sponsorshipIdDAADPROBAL 50754442
dc.description.sponsorshipIdCAPES: NR-8248/12-5
dc.description.sponsorshipIdUS Department of EnergyDE-AC02-05CH11231
dc.format.extent1958-1964
dc.identifierhttp://dx.doi.org/10.1107/S0907444913018003
dc.identifier.citationActa Crystallographica Section D-biological Crystallography. Hoboken: Wiley-blackwell, v. 69, p. 1958-1964, 2013.
dc.identifier.doi10.1107/S0907444913018003
dc.identifier.issn0907-4449
dc.identifier.lattes9162508978945887
dc.identifier.orcid0000-0003-2460-1145
dc.identifier.urihttp://hdl.handle.net/11449/112905
dc.identifier.wosWOS:000325403900010
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofActa Crystallographica Section D: Biological Crystallography
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleStructure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificusen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes9162508978945887[6]
unesp.author.orcid0000-0003-2460-1145[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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