Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses

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dc.contributor.authorde Matteis, Rafael [UNESP]
dc.contributor.authorPereira, Guilherme L. [UNESP]
dc.contributor.authorCasarotto, Letícia T. [UNESP]
dc.contributor.authorTavernaro, Anna Júlia S. [UNESP]
dc.contributor.authorSilva, Josineudson Augusto II. V. [UNESP]
dc.contributor.authorChardulo, Luís Artur L. [UNESP]
dc.contributor.authorCuri, Rogério A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:53:15Z
dc.date.available2019-10-06T16:53:15Z
dc.date.issued2018-12-01
dc.description.abstractThe objectives of this study were to evaluate differences between the racing and cutting lines of Quarter Horses in the allele frequencies of polymorphisms identified in the chromosomal region of the myostatin gene (MSTN, ECA18) and to analyze the association of polymorphisms in this chromosomal region with the estimated breeding values (EBVs) for racing performance, given by the maximum speed index, height at withers (HW), thoracic perimeter (TP), and body length (BL) in the racing line, and with EBVs for HW, TP, and BL in the cutting line. Genomic, phenotypic, and pedigree data from 420 horses of both sexes, registered in the Brazilian Association of Quarter Horse breeders, were used (352 of racing line and 68 of cutting line). In the genome region studied (MSTN ± 2 Mb), 46 SNPs and one SINE (ERE1) shared among the cutting and racing lines were identified, and the allele frequencies of 32 SNPs and the one SINE differed significantly between the two lines (P <.05). Furthermore, the part of this region closest to the MSTN (±1 Mb) was found to be less polymorphic in the racing line. Regarding phenotype-associated polymorphisms (unadjusted P <.05), those related to HW in the racing line are highlighted because of their large number and extensive linkage disequilibrium. In addition, these markers exhibited significantly higher frequencies of the favorable allele compared to the cutting line.en
dc.description.affiliationDepartment of Animal Science College of Agriculture and Veterinary Science São Paulo State University (UNESP)
dc.description.affiliationDepartment of Animal Breeding and Nutrition College of Veterinary and Animal Science São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Animal Science College of Agriculture and Veterinary Science São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Animal Breeding and Nutrition College of Veterinary and Animal Science São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/20207-1
dc.format.extent75-83
dc.identifierhttp://dx.doi.org/10.1016/j.jevs.2018.09.007
dc.identifier.citationJournal of Equine Veterinary Science, v. 71, p. 75-83.
dc.identifier.doi10.1016/j.jevs.2018.09.007
dc.identifier.issn0737-0806
dc.identifier.lattes3514713413919126
dc.identifier.orcid0000-0001-6289-0406
dc.identifier.scopus2-s2.0-85055109515
dc.identifier.urihttp://hdl.handle.net/11449/189819
dc.language.isoeng
dc.relation.ispartofJournal of Equine Veterinary Science
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectERE1
dc.subjectHorse
dc.subjectMolecular markers
dc.subjectQTL
dc.subjectSNP
dc.subjectSpeed
dc.titleVariants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horsesen
dc.typeArtigo
unesp.author.lattes3514713413919126[7]
unesp.author.orcid0000-0001-6289-0406[7]

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