Decrease in circulating glucose, insulin and leptin levels and improvement in insulin resistance at 1 and 3 months after gastric bypass

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dc.contributor.authorPinho Ramos, Adriana Pelegrino
dc.contributor.authorAzevedo de Abreu, Marcia Regina
dc.contributor.authorVendramini, Regina Célia [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorPepato, Maria Teresa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Ribeirao Preto
dc.date.accessioned2014-05-20T13:24:33Z
dc.date.available2014-05-20T13:24:33Z
dc.date.issued2006-10-01
dc.description.abstractBackground: Hyperglycemia, insulin resistance and hyperleptinemia are some of the consequences of obesity. Gastric bypass for morbid obesity provides gastric restriction with decreased energy absorption. To confirm and extend previous reports in the literature, We evaluated the plasma glucose, serum insulin and leptin and insulin resistance of patients preoperatively and 1 and 3 months after Roux-en-Y gastric bypass (RYGBP).Methods: We determined body mass index (BMI), plasma glucose (glucose-oxidase method), serum leptin (immunoassay) and insulin (chemiluminescent immunometric assay), and insulin resistance index (IRI) by Homeostasis Model Assessment (HOMA) of 20 patients with morbid obesity both preoperatively and 1 and 3 months after RYGBP.Results: Patients showed a mean decrease in weight of 8 kg/month. Glycemia was above reference levels in 65% of the preoperative patients but dropped significantly 1 month postoperatively, serum insulin and leptin levels and the HOMA index also decreasing significantly in the same period. The percentage of patients with preoperative elevated serum insulin and leptin relative to reference levels decreased significantly following RYGBP. We also observed a weak but significant correlation between BMI and glucose, BMI and insulin, and leptin and insulin.Conclusions: the beneficial effects of bariatric surgery are already noticeable 1 month postoperatively, the reduction in insulin levels being more important for leptin reduction than decreased BMI. Leptin appeared to be subject to multifactorial control and showed a larger reduction than body weight.en
dc.description.affiliationUniv Estadual Paulista, Dept Anal Clin, Fac Ciências Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Ribeirao Preto, Lab Anal Clin, Curso Ciências Farmaceut, Ribeirao Preto, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Anal Clin, Fac Ciências Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.format.extent1359-1364
dc.identifierhttp://dx.doi.org/10.1381/096089206778663706
dc.identifier.citationObesity Surgery. Toronto: F D-communications Inc., v. 16, n. 10, p. 1359-1364, 2006.
dc.identifier.doi10.1381/096089206778663706
dc.identifier.issn0960-8923
dc.identifier.lattes7641979287850489
dc.identifier.urihttp://hdl.handle.net/11449/7652
dc.identifier.wosWOS:000241209200016
dc.language.isoeng
dc.publisherF D-communications Inc
dc.relation.ispartofObesity Surgery
dc.relation.ispartofjcr3.895
dc.relation.ispartofsjr1,396
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmorbid obesitypt
dc.subjectbariatric surgerypt
dc.subjectgastric bypasspt
dc.subjectweight losspt
dc.subjectinsulin resistancept
dc.subjectserum insulinpt
dc.subjectserum leptinpt
dc.subjectplasma glucosept
dc.titleDecrease in circulating glucose, insulin and leptin levels and improvement in insulin resistance at 1 and 3 months after gastric bypassen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderF D-communications Inc
unesp.author.lattes7641979287850489
unesp.author.orcid0000-0003-4927-7599[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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